Clinical Features and Prognosis of Invasive Ventilation in Hospitalized Patients with COVID-19: A Retrospective Study

AUTHORS

Poupak Rahimzadeh 1 , Hamid Reza Faiz 2 , Reza Farahmandrad 2 , Babak Hassanlouei ORCID 3 , Azadeh Habibi 2 , Setareh Hedayati Emami 2 , Saied Amniati ORCID 2 , *

1 Pain Research Center, Department of Anesthesiology and Pain Medicine, Iran University of Medical Sciences, Tehran, Iran

2 Rasoul Akram Hospital Clinical Research Development Center ( RCRDC), Tehran, Iran

3 Department of Epidemiology, School of Public Health, Iran University of Medical Sciences, Tehran, Iran

How to Cite: Rahimzadeh P , Faiz H R , Farahmandrad R , Hassanlouei B , Habibi A, et al. Clinical Features and Prognosis of Invasive Ventilation in Hospitalized Patients with COVID-19: A Retrospective Study, Anesth Pain Med. Online ahead of Print ; 10(6):e108773. doi: 10.5812/aapm.108773.

ARTICLE INFORMATION

Anesthesiology and Pain Medicine: 10 (6); e108773
Published Online: December 19, 2020
Article Type: Research Article
Received: August 31, 2020
Revised: December 5, 2020
Accepted: December 5, 2020
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Abstract

Background: World Health Organization (WHO) declared that the outbreak of COVID-19 constituted a public health emergency of global concern.

Objectives: Owing to limited data on critically ill patients admitted to ICU, we aimed to describe the clinical characteristics and prognosis of these patients based on ventilatory variables and clinical features.

Methods: In this retrospective study, 45 critically ill patients with laboratory-confirmed COVID-19 who were admitted to Intensive Care Unit (ICU) wards of the hospital from April 8 to May 9, 2020, were enrolled. Medical files of the patients were reviewed, and demographic and clinical characteristics, laboratory data, lung CT scan findings, causes of intubation, and outcomes of the patients were all collected.

Results: The median age of the patients was 67 years (range 22 to 91), 64% were men, and hypertension was the most common comorbidity. History of close contact with previously confirmed patients was positive in 62.2% of the patients. The mean time from symptom onset to hospital admission was 5.98 ± 2.93 days. The most common symptoms at the onset of illness were dyspnea (95.6%), and gastrointestinal symptoms (22.2%) were rare. The average length of the intubation was 4.84 ± 3.28 days. The distribution of intubation causes in the deceased patients was significantly more than the recovered patients (P = 0.031). The mean score of lung CT involvement in deaths (370.26 ± 207.50) was significantly higher than the recovered patients (235.71 ± 81.21) (P = 0.042). Length of the intubation had a statistically direct correlation with respiratory rate (P = 0.03).

Conclusions: Most of the critically ill patients admitted to ICU were older men and had poor outcomes with a high mortality rate. Furthermore, the score of chest CT involvement and respiratory rate are important prognostic factors in determining the severity of the illness, requiring ventilatory support, and outcome.

1. Background

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV2) is a new strain of coronavirus, which was first detected in Wuhan, China, in December 2019 (1, 2). Thus far, coronavirus disease 2019 (COVID-19), caused by SARS-CoV2, has rapidly infected millions of people around the world and has become an emerging health threat (3). On February 19, 2020, Iran reported its first cases diagnosed with COVID-19 in Qom; subsequently, the increasing number of cases recorded in Qom, and finally, throughout all 31 provinces of the country (4).

COVID-19 is a novel disease with wide clinical manifestations, encompassing asymptomatic or mild upper respiratory tract illness to severe viral pneumonia with acute respiratory distress syndrome (ARDS) and even death (5). Whereas most infected people develop mild to moderate illness and recover without hospitalization, about 14% present with severe symptoms that require hospital care, and one-third of hospitalized patients need invasive mechanical ventilation (6). Critically ill patients with COVID-19 may develop ARDS, septic shock, sepsis, cardiac injury, acute kidney injury, and multi-organ dysfunction (7). Although risk factors for severe illness remain unclear, comorbidity and older age have been reported as likely important factors for poor prognosis and death (8, 9).

To date, no specific medication or immunomodulatory therapy has yet been approved for the treatment of COVID-19, so the management of critically ill patients is similar to the management of most viral pneumonia, and supportive therapy to control symptoms and to protect multi-organ function is the priority of the management (10). Therefore, due to the increase in the number of hospitalized patients and limited ICU capacity, identifying clinical characteristics and hospital course of severe and ventilated patients with COVID-19 is crucial to guide decision making regarding ICU capacities and allocation of resources to decrease the mortality rate. Most of the previous studies have just reported the general epidemiological, and clinical characteristics of hospital admitted patients with COVID-19, and there are limited data about the clinical course of severe cases of COVID-19 (7, 9, 11-14). Recently, a case series from Italy have reported detailed information on ventilatory parameters, clinical and laboratory characteristics and have determined prognosis and risk factors of ventilated patients with COVID-19 admitted to ICU. Their results showed that older age and pre-admission hypertension are the main mortality risk factors (15).

2. Objectives

Accordingly, we aimed to describe the clinical characteristics and prognosis of critically ill patients with COVID-19 based on ventilatory variables and clinical features.

3. Methods

3.1. Study Population

This retrospective study was done at a teaching hospital, Tehran, Iran, which is one of the referral centers for the COVID-19. The inclusion criteria were all consecutive critically ill patients with laboratory-confirmed COVID-19 who were admitted to intensive care unit (ICU) wards or transferred from wards to ICU of the hospital from April 8 to May 9, 2020. The patients without any imaging documents, either chest X-ray (CXR) or chest CT were excluded. Drug history of all enrolled cases was recorded in detail, but this information was not analyzed. All of the deaths caused by COVID-19 directly or indirectly and also caused by COVID-19 complication were recorded as COVID-19 death. Confirmed infection was defined as positive real-time polymerase chain reaction (RT-PCR) to SARS-CoV-2 in their nasopharyngeal specimens (10). Critically ill patients were defined as intubated patients admitted to ICU who required mechanical ventilation. The respiratory rate of the patients was recorded immediately before intubation, and in case of being higher than the determined limit defined as tachypnea and the relationship between tachypnea with intubation time was then analyzed. The Ethics Commission of Iran University of Medical Sciences approved this study, and written informed consent was waived due to the nature of retrospective chart review.

3.2. Data Collection

Medical files of the patients were reviewed for data collection. We obtained data on demographic, signs and symptoms upon hospital admission, comorbidities, smoking history, contact exposure, history of influenza vaccination, laboratory data, lung CT scan findings, time from symptoms to hospital admission, time from hospital admission to intubation, length of the intubation, causes of intubation, and outcome data. All data were collected by two trained investigators.

Causes of intubation were classified into hypoxia and hypercapnia, hypoxia and tachypnea and hypercapnia, hypoxia and tachypnea, hypoxia, hemodynamic instability, and cardiopulmonary arrest. Hypoxia was defined as SPO2 under 90% or PaO2 under 60 mmHg, hypercapnia was defined as PaCO2 above 50 mmHg, and tachypnea was defined as respiratory rate above 30/min.

Lung CT findings were graded on a scale of 1 - 6 based on a classification system which had been previously evaluated in the other diseases: 1 normal; 2 ground-glass; 3 consolidation; 4 ground-glass with traction bronchiolectasis or bronchiectasis; 5 consolidation with traction bronchiolectasis or bronchiectasis, and 6 honeycombing (16, 17). The presence of each of these abnormalities was assessed in three (upper, middle, and lower) zones of each lung. The percentage of involvement in each zone was estimated based on visual criteria by two expert radiologists. The abnormality score for each zone was calculated by multiplying the percentage area by the point value (1-6). The six-zone scores were averaged to determine the total score for each abnormality in each patient. The overall CT score for each patient was obtained by adding the six averaged scores.

3.3. Statistical Analysis

All statistical analyses were performed with the Statistical Package for Social Sciences version 20.0 (SPSS Inc., Chicago, IL, USA). Means ± standard deviation (SD) and median (with an interquartile range = IQR = Q1-Q3) were used for continuous variables, and frequencies and proportions were used for categorical variables. Variables of both groups (death or survival) were compared using χ2 tests or Fisher’s Exact test for proportions and unpaired t-tests for means. Pearson correlation coefficient was used to evaluate the association between characteristics with ventilatory variables. A P-value of less than 0.05 was considered statistically significant.

4. Results

Fifty-four critically ill patients with confirmed COVID-19 were admitted to the ICU of the teaching hospital and received mechanical ventilation. Overall, 38 (84.4%) cases died, and 7 (15.6%) patients were discharged home. The median age of the patients was 67 years (range 22 to 91), and 29 of the 45 patients (64%) were male. Most of the patients had comorbidity (35 [77.7%]), including hypertension (23 [51.1%]), diabetes (19 [42.2%]), cardiovascular disease (6 [13.3%]), and asthma (3 [6.7%]). In addition, 8 (17.8%) patients have a history of smoking, 6(13.3%) patients had a history of receiving annual influenza vaccine, and 28 (62.2%) patients had a history of close contact with previously confirmed patients. Table 1 represents the baseline characteristics of the patients.

Table 1. Baseline Characteristics of Critically Ill Patients with COVID-19
Characteristics Total Number of Patients (%)
Age, mean ± SD65.39 ± 14.60
Gender
Female16 (35.6)
Male29 (64.4)
Asthma
No42 (93.3)
Yes3 (6.7)
Smoking history
No37 (82.2)
Yes8 (17.8)
Diabetes
No26 (57.8)
Yes19 (42.2)
Hypertension
No22 (48.9)
Yes23 (51.1)
Chronic heart failure
No39 (86.7)
Yes6 (13.3)
Received annual influenza vaccine
No39 (86.7)
Yes6 (13.3)
History of close contact with infected patients
Unknown17 (37.8)
Yes28 (62.2)
Outcome
Recover7(15.6)
Death38 (84.6)

The mean time from symptoms to hospital admission was 5.98 ± 2.93 days, and from illness onset to dyspnea was 2.73 ± 3.07 days. Dyspnea (95.6%), SPO2 depression (93.3%), and fever (80%) were the most common signs and symptoms upon hospital admission. Gastrointestinal symptoms were rare (diarrhea [13.3%], and nausea and vomiting [8.9%]) (Table 2). The average hospital admission to intubation time was 2.33 ± 2.65 days. The average length of the intubation was 4.84 ± 3.28 days. The causes of intubation were hypoxia and tachypnea 13 (28.88%), hypoxia and hypercapnia 10 (22.22%), hypoxia 8 (17.77%), hypoxia and tachypnea and hypercapnia 7 (15.55%), hemodynamic instability 4 (8.88%), and cardiopulmonary arrest 3 (6.66%). Distribution of intubation causes in the deceased patients was significantly higher in the recovered patients (P = 0.031) (Table 3).

Table 2. Signs and Symptoms Upon Hospital Admission of Critically Ill Patients with COVID-19
Signs and Symptoms Upon Hospital AdmissionTotal Number of Patients (%)
Fever
No9 (20)
Yes36 (80)
Dyspnea
No2 (4.4)
Yes43 (95.6)
SPO2 < 93%
No3 (6.7)
Yes42 (93.3)
Myalgia or fatigue
No25 (55.6)
Yes20 (44.4)
Cough
No10 (22.2)
Yes35 (77.8)
Nausea and vomiting
No41 (91.1)
Yes4 (8.9)
Diarrhea
No39 (86.7)
Yes6 (13.3)
Sore throat
No37 (82.2)
Yes8 (17.8)
Table 3. Distribution of Intubation Causes Between Deaths and Recovered Patients (P-Value = 0.031)
Causes of IntubationTotal (%)Recovered Patients (N = 7)Deaths (N = 38)
Hypoxia and hypercapnia10 (22.2)5 (71.4)5 (13.2)
Hypoxia, tachypnea, and hypercapnia7 (15.6)0 (0.0)7 (18.4)
Hypoxia and tachypnea13 (28.9)1 (14.3)12 (31.5)
Hypoxia8 (17.8)1 (14.3)7 (18.4)
Hemodynamic instability4 (8.9)0 (0.0)4 (10.5)
Cardiopulmonary arrest3 (6.7)0 (0.0)3 (7.9)

The mean score of lung CT findings in the deceased patients (370.26 ± 207.50) was significantly higher than the recovered patients (235.71 ± 81.21) (P = 0.042). Additionally, we analyzed the association of clinical and laboratory variables with causes of intubation (Table 4). Results show no statistically correlation between LDH, length of the intubation, SPO2, pH, and cause of intubation (P > 0.05), while respiratory rate, PaO2, PaCO2, and CT scores had a statistically direct correlation (P < 0.05). The correlation between average hospital admission to intubation time and average length of the intubation was studied with variables LDH, SPO2, pH, respiratory rate, PaO2, PaCO2 that results showed a statistically direct correlation between average hospital admission to intubation time and PaCO2 (P = 0.023) and a statistically direct correlation between the average length of the intubation and respiratory rate (P = 0.03). The correlation between other variables was not significant (P > 0.05) (Table 5).

Table 4. Association Between Clinical and Laboratory Variables with Causes of Intubation
CharacteristicsNumberMean ± SDP-Value
LDH0.351
Hypoxia and hypercapnia10942.30 ± 160.55
Hypoxia, tachypnea, and hypercapnia7951.86 ± 299.61
Hypoxia, and tachypnea131213.9 ± 399.64
Hypoxia81093.75 ± 193.63
Hemodynamic instability41103.75 ± 175.65
Cardiopulmonary arrest3939.00 ± 161.65
Total451063.31 ± 289.32
Duration of mechanical ventilation, d0.073
Hypoxia and hypercapnia107.50 ± 3.56
Hypoxia, tachypnea, and hypercapnia74.57 ± 3.10
Hypoxia and tachypnea133.62 ± 2.21
Hypoxia85.13 ± 3.94
Hemodynamic instability43.75 ± 2.21
Cardiopulmonary arrest32.67 ± 2.08
Total454.84 ± 3.28
SPO20.574
Hypoxia and hypercapnia1069.10 ± 8.34
Hypoxia, tachypnea, and hypercapnia763.71 ± 10.16
Hypoxia and tachypnea1357.08 ± 16.59
Hypoxia867.38 ± 2.32
Hemodynamic instability463.50 ± 14.43
Cardiopulmonary arrest367.00 ± 19.31
Total4563.84 ± 12.57
pH0.175
Hypoxia and hypercapnia107.35 ± 0.0870
Hypoxia, tachypnea, and hypercapnia77.27 ± 0.1575
Hypoxia and tachypnea137.35 ± 0.0906
Hypoxia87.39 ± 0.0261
Hemodynamic instability47.35 ± 0.0544
Cardiopulmonary arrest37.29 ± 0.1997
Total457.34 ± 0.1041
Respiratory rate< 0.001
Hypoxia and hypercapnia1023.90 ± 2.28
Hypoxia, tachypnea, and hypercapnia738.43 ± 3.82
Hypoxia and tachypnea1334.92 ± 4.64
Hypoxia825.13 ± 0.35
Hemodynamic instability436.00 ± 7.34
Cardiopulmonary arrest327.67 ± 7.37
Total4530.89 ± 7.01
PaO20.01
Hypoxia and hypercapnia1035.30 ± 10.84
Hypoxia, tachypnea, and hypercapnia746.42 ± 10.65
Hypoxia and tachypnea1327.23 ± 11.42
Hypoxia836.50 ± 9.28
Hemodynamic instability433.87 ± 6.63
Cardiopulmonary arrest347.333 ± 11.37
Total4535.58 ± 12.12
PaCO2< 0.001
Hypoxia and hypercapnia1055.60 ± 3.71
Hypoxia, tachypnea, and hypercapnia773.43 ± 19.57
Hypoxia and tachypnea1338.23 ± 8.41
Hypoxia834.75 ± 4.83
Hemodynamic instability438.75 ± 5.79
Cardiopulmonary arrest381.33 ± 59.53
Total4549.87 ± 22.30
Lung CT findings score0.014
Hypoxia and hypercapnia10232.00 ± 30.111
Hypoxia, tachypnea, and hypercapnia7304.29 ± 147.858
Hypoxia and tachypnea13463.08 ± 256.950
Hypoxia8337.50 ± 231.686
Hemodynamic instability4457.50 ± 96.047
Cardiopulmonary arrest3240.00 ± 20.000
Total45349.33 ± 198.842
Table 5. The Pearson Correlations Between Average Hospital Admission to Intubation Time and Average Length of the Intubation with LDH, SPO2, PH, Respiratory Rate, PaO2, and PaCO2
Days From Hospital Admission to Need Mechanical Ventilation, dDuration of Mechanical Ventilation, dLDHSPO2PHRespiratory RatePao2Pco2
Days from hospital admission to need mechanical ventilation, d
Pearson correlation10.030-0.1080.109-0.1740.1670.1690.338a
Sig. (2-tailed)0.8470.4800.4750.2530.2730.2670.023
Number4545454545454545
Duration of mechanical ventilation, d
Pearson correlation0.0301-0.1460.0850.075-0.325a-0.2200.070
Sig. (2-tailed)0.8470.3380.5800.6250.0300.1470.645
Number4545454545454545

aCorrelation is significant at 0.05 level (2-tailed).

5. Discussion

This retrospective study describes the clinical course and outcomes of 54 critically ill patients with laboratory-confirmed COVID-19 infection who intubated and admitted in ICU wards. As mentioned in previous studies, the population in this study mostly consisted of men (64%) and was generally older (median age, 67 years; range, 22 - 91 years) than previous case series admitted to ICU in China, Italy, and America (11-15). Although previous evidence suggests that older and male patients are the most susceptible individuals to COVID-19, we cannot consider older age and male gender as a risk factor for admission to the ICU or poor prognosis.

In our case series, dyspnea followed by SPO2 depression, fever, and cough were the most prevalent symptoms on admission among critically ill patients with COVID-19, which is in accordance with previous studies (18). It seems that clinical presentations of COVID-19 are relatively similar to other betacoronavirus infections. Furthermore, less than 15% of the patients had gastrointestinal symptoms, and this was consistent with the results from other previous studies. However, the incidence of gastrointestinal symptoms in patients with MERS-CoV or SARS-CoV infection has been reported about 20% - 25% (19, 20).

In accordance with the recent reports, our study reported that 77.7% of the critically ill patients had at least one comorbidity. This is similar to what was reported by Wang et al. (72.2%), and it was 86% in another case series in the USA (13, 21). Hypertension was the most common comorbidity in our study, this is similar to what was reported by other previous studies (18). Moreover, the majority of the patients (62.2%) had a history of close contact with infected patients. This was concordant with the results from Bhatraju et al. (13) reported 54% had recent contact with an infected patient.

Previous studies reported a wide range of mortality rates among critically ill patients admitted to ICU, from 16% to 38%, 62%, 67%, and 80% (12-15, 22-24). In our study, overall outcomes were poor in severe patients who received ICU care, and the mortality rate (84.6%) was considerably higher than other studies. In fact, we reported the final outcomes of the patients, but previous studies just followed the patients for a limited time. Therefore, the majority of the patients were still in the ICU or hospital at the time of gathering data, and there is an underestimation in reporting mortality rate by previous studies. For example, a large Italian case series reported 26% mortality rate at 5 weeks after ICU admission; however, more than 50% of the patients were still in the ICU at the time of submission, and their outcome remains uncertain (14). In addition, we just reported data from intubated patients and those requiring mechanical ventilation. In a case series from Wuhan, the mortality rate among critically ill patients was 62%, and it was 81% among those requiring mechanical ventilation (8).

In agreement with the previous reports, our study confirmed that all patients had abnormal findings in chest CT scan, and bilateral multiple lobular and subsegmental areas of consolidation were the most frequent chest CT findings among ICU patients (8). Additionally, we observed that non-survivors had a significantly higher score of lung CT involvement than survivors. This finding supports the score of chest CT involvement as a prognostic factor in outcomes of severe patients with COVID-19.

Our findings revealed that the majority of patients in this case series intubated and required mechanical ventilation because of hypoxemic, hypercapnic, and tachypneic respiratory failure. This finding supports the results of previous studies that reported respiratory failure and developed ARDS were the main reasons for intubation and ICU admission among critically ill patients with COVID-19 (15, 18). Furthermore, respiratory rate, PaO2, PaCO2, and CT score had a statistically direct correlation with the distribution causes of intubation.

As new findings, our study demonstrated that the length of the intubation had a direct correlation with respiratory rate. In fact, the length of intubation would be longer in critically ill patients who had higher respiratory rates on admission. Therefore, we can consider the respiratory rate as a prognostic factor for the length of the intubation. This is not investigated in other studies. We can argue that the patients with higher respiratory rate have more lung involvement and greater decline in pulmonary function, so they will require mechanical ventilation and oxygen support longer than other patients.

Our study has some strong points that must be highlighted. First, the data represents certain outcomes of the patients, and the patients were fully recovered or deceased at the time of data collection. Second, we investigated the causes of intubation and scoring lung CT involvement among intubated patients as new aspects of the clinical features of critically ill patients with COVID-19. On the other hand, the small sample size and single-center study were the main limitations of the current study. Finally, we suggest that this study could be performed on a larger sample size and multicenter to clarify risk factors and prognostic factors, especially among intubated patients with COVID-19.

In summary, it was concluded that most of the critically ill patients admitted to ICU were older men and had poor outcomes with a high mortality rate. Furthermore, the score of chest CT involvement and respiratory rate are important prognostic factors in determining the severity of illness, requiring ventilatory support, and outcome. Considering the causes of intubation, especially respiratory distress among critically ill patients, the importance of earlier cardiac monitoring and ventilatory support, must be highlighted.

Footnotes

References

  • 1.

    Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, et al. A Novel Coronavirus from Patients with Pneumonia in China, 2019. N Engl J Med. 2020;382(8):727-33. doi: 10.1056/NEJMoa2001017. [PubMed: 31978945]. [PubMed Central: PMC7092803].

  • 2.

    Gralinski LE, Menachery VD. Return of the Coronavirus: 2019-nCoV. Viruses. 2020;12(2). doi: 10.3390/v12020135. [PubMed: 31991541]. [PubMed Central: PMC7077245].

  • 3.

    World Health Organization. Naming the coronavirus disease (COVID-19) and the virus that causes it. 2020.

  • 4.

    Abdi M. Coronavirus disease 2019 (COVID-19) outbreak in Iran: Actions and problems. Infect Control Hosp Epidemiol. 2020;41(6):754-5. doi: 10.1017/ice.2020.86. [PubMed: 32192541]. [PubMed Central: PMC7137533].

  • 5.

    Chan JF, Yuan S, Kok K, To KK, Chu H, Yang J, et al. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. Lancet. 2020;395(10223):514-23. doi: 10.1016/s0140-6736(20)30154-9.

  • 6.

    Team NCPERE. The Epidemiological Characteristics of an Outbreak of 2019 Novel Coronavirus Diseases (COVID-19) — China, 2020. China CDC Weekly. 2020;2(8):113-22. doi: 10.46234/ccdcw2020.032.

  • 7.

    Yang X, Yu Y, Xu J, Shu H, Xia J, Liu H, et al. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. Lancet Respir Med. 2020;8(5):475-81. doi: 10.1016/s2213-2600(20)30079-5.

  • 8.

    Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497-506. doi: 10.1016/S0140-6736(20)30183-5. [PubMed: 31986264]. [PubMed Central: PMC7159299].

  • 9.

    Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020;395(10229):1054-62. doi: 10.1016/s0140-6736(20)30566-3.

  • 10.

    Pergolizzi JV, Jr, Magnusson P, LeQuang JA, Breve F, Paladini A, Rekatsina M, et al. The Current Clinically Relevant Findings on COVID-19 Pandemic. Anesth Pain Med. 2020;10(2). e103819. doi: 10.5812/aapm.103819. [PubMed: 32754437]. [PubMed Central: PMC7352949].

  • 11.

    Guan WJ, Ni ZY, Hu Y, Liang WH, Ou CQ, He JX, et al. Clinical Characteristics of Coronavirus Disease 2019 in China. N Engl J Med. 2020;382(18):1708-20. doi: 10.1056/NEJMoa2002032. [PubMed: 32109013]. [PubMed Central: PMC7092819].

  • 12.

    Arentz M, Yim E, Klaff L, Lokhandwala S, Riedo FX, Chong M, et al. Characteristics and Outcomes of 21 Critically Ill Patients With COVID-19 in Washington State. JAMA. 2020;323(16):1612-4. doi: 10.1001/jama.2020.4326. [PubMed: 32191259]. [PubMed Central: PMC7082763].

  • 13.

    Bhatraju PK, Ghassemieh BJ, Nichols M, Kim R, Jerome KR, Nalla AK, et al. Covid-19 in Critically Ill Patients in the Seattle Region - Case Series. N Engl J Med. 2020;382(21):2012-22. doi: 10.1056/NEJMoa2004500. [PubMed: 32227758]. [PubMed Central: PMC7143164].

  • 14.

    Grasselli G, Zangrillo A, Zanella A, Antonelli M, Cabrini L, Castelli A, et al. Baseline Characteristics and Outcomes of 1591 Patients Infected With SARS-CoV-2 Admitted to ICUs of the Lombardy Region, Italy. JAMA. 2020;323(16):1574-81. doi: 10.1001/jama.2020.5394. [PubMed: 32250385]. [PubMed Central: PMC7136855].

  • 15.

    Zangrillo A, Beretta L, Scandroglio AM, Monti G, Fominskiy E, Colombo S, et al. Characteristics, treatment, outcomes and cause of death of invasively ventilated patients with COVID-19 ARDS in Milan, Italy. Crit Care Resusc. 2020. [PubMed: 32353223].

  • 16.

    Pournajafian AR, Ghodraty MR, Faiz SH, Rahimzadeh P, Goodarzynejad H, Dogmehchi E. Comparing GlideScope Video Laryngoscope and Macintosh Laryngoscope Regarding Hemodynamic Responses During Orotracheal Intubation: A Randomized Controlled Trial. Iran Red Crescent Med J. 2014;16(4). e12334. doi: 10.5812/ircmj.12334. [PubMed: 24910788]. [PubMed Central: PMC4028761].

  • 17.

    Ichikado K, Suga M, Muranaka H, Gushima Y, Miyakawa H, Tsubamoto M, et al. Prediction of prognosis for acute respiratory distress syndrome with thin-section CT: validation in 44 cases. Radiology. 2006;238(1):321-9. doi: 10.1148/radiol.2373041515. [PubMed: 16293804].

  • 18.

    Fu L, Wang B, Yuan T, Chen X, Ao Y, Fitzpatrick T, et al. Clinical characteristics of coronavirus disease 2019 (COVID-19) in China: A systematic review and meta-analysis. J Infect. 2020;80(6):656-65. doi: 10.1016/j.jinf.2020.03.041. [PubMed: 32283155]. [PubMed Central: PMC7151416].

  • 19.

    Assiri A, Al-Tawfiq JA, Al-Rabeeah AA, Al-Rabiah FA, Al-Hajjar S, Al-Barrak A, et al. Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study. Lancet Infect Dis. 2013;13(9):752-61. doi: 10.1016/S1473-3099(13)70204-4. [PubMed: 23891402]. [PubMed Central: PMC7185445].

  • 20.

    Lee N, Hui D, Wu A, Chan P, Cameron P, Joynt GM, et al. A major outbreak of severe acute respiratory syndrome in Hong Kong. N Engl J Med. 2003;348(20):1986-94. doi: 10.1056/NEJMoa030685. [PubMed: 12682352].

  • 21.

    Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, et al. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China. JAMA. 2020;323(11):1061-9. doi: 10.1001/jama.2020.1585. [PubMed: 32031570]. [PubMed Central: PMC7042881].

  • 22.

    Rahimzadeh P, Amniati S, Farahmandrad R, Faiz SHR, Hedayati Emami S, Habibi A. Clinical Characteristics of Critically Ill Patients Infected with COVID-19 in Rasoul Akram Hospital in Iran: A Single Center Study. Anesth Pain Med. 2020;10(5). e107211. doi: 10.5812/aapm.107211.

  • 23.

    Hassani V, Amniati S, Ahmadi A, Mohseni M, Sehat-Kashani S, Nikoubakht N, et al. Emergency Tracheostomy in Two Airway Trauma Patients Suspected of COVID-19: A Case Report. Anesth Pain Med. 2020;10(4). e104648. doi: 10.5812/aapm.104648. [PubMed: 33134149]. [PubMed Central: PMC7539045].

  • 24.

    Papa A, Di Dato MT, Buonavolonta P, Saracco E, Salzano AM, Casale B. Clinical Management of Il-6 Driven Cytokine Storm Related to COVID-19 in a Patient with Recent Spinal Cord Stimulator Implants: A Case Report. Anesth Pain Med. 2020;10(4). e104151. doi: 10.5812/aapm.104151. [PubMed: 33134148]. [PubMed Central: PMC7539055].

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