Propofol is Effective to Depress Fentanyl-Induced Cough during Induction of Anesthesia


Abbas Sedighinejad ORCID 1 , Bahram Naderi Nabi ORCID 1 , * , Mohammad Haghighi ORCID 1 , Vali Imantalab ORCID 1 , Sodabe Hadadi ORCID 1 , Reza Erfani Sayar ORCID 1 , Ahmadreza Mirblook 2

1 Anesthesiology Department, Guilan University of Medical Sciences, [email protected], Iran

2 Orthopaedy Department, Guilan University of Medical Sciences, Iran

How to Cite: Sedighinejad A, Naderi Nabi B, Haghighi M, Imantalab V, Hadadi S, et al. Propofol is Effective to Depress Fentanyl-Induced Cough during Induction of Anesthesia, Anesth Pain Med. Online ahead of Print ; 2(4):170-3. doi: 10.5812/aapm.8383.


Anesthesiology and Pain Medicine: 2 (4); 170-3
Published Online: March 26, 2013
Article Type: Research Article
Received: October 2, 2012
Accepted: December 8, 2012


Background: Various attempts have been made to reduce the incidence of fentanyl-induced cough during anesthesia induction. We hypothesized that an appropriate dose of propofol might suppress fentanyl-induced cough.

Objectives: A study had been designed to observe the effects of propofol on a fentanyl-induced cough during anesthesia induction.

Patients and Methods: We performed a randomized, double-blind study to evaluate the effect of the pre-emptive use of minimal dose intravenous propofol (20 mg) on the incidence of cough caused by a larger bolus of intravenous fentanyl. Group 1 patients were given fentanyl at a dosage of 4 g/kg. Group 2 received 4g/kg fentanyl and 20 mg propofol. The two groups were evaluated in 0, 5 and 10 second intervals following the injection of fentanyl.

Results: Mean age, weight, and, height was 35 10.45, 67.99 10.92, and 165.33 31.84 respectively. The incidence of fentanyl induced cough was 29 (74.4%) in placebo group compared with 10 (25.6%) in the propofol group. There was a significant difference in the incidence and severity of cough between group 1 and 2 (P < 0.0001). This study also showed that propofol could decrease cough incidence in patients who smoke.

Conclusions: Priming dose of propofol (20mg) one minute prior to fentanyl injection was effective in suppressing a fentanyl-induced cough.

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