Gastric cancer as a multifactorial disease


Shahrokh Iravani 1 , *

1 Associated Professor, Faculty of Medicine, AJA University of Medical Sciences, Tehran, Iran, Iran

How to Cite: Iravani S. Gastric cancer as a multifactorial disease, Ann Mil Health Sci Res. 2013 ; 11(2):e66570.


Annals of Military and Health Sciences Research: 11 (2); e66570
Published Online: June 20, 2013
Article Type: Review Article
Received: February 05, 2013
Accepted: May 20, 2103


Background: Gastric cancer is the fourth most common cancer and it is known as the second leading cause of cancer deaths. Carcinogenesis ius a multifactorial process that is dependent to parallel effects of environment and genetic. Environmental risk factors for gastric cancer are Helicobacter pylori infection, life style and nutrition.

Materials and Methods: This study was a narrative review and the results of the collection and interpretation of available information on the causes of gastric cancer, Methods of diagnosis and treatment.

Results: Helicobacter pylori infection, genetic predisposition and environmental factors such as nutrition and health are risk factors of gastric cancer. But these factors have interactions. A poor nutrition increase inflammatory effect of bacteria and genetic background causes the progression of mild inflammation to ulcer, atrophy and ultimately it causes malignancy and cancer.

Conclusion: Delayed diagnosis, treatment and prevention of gastric cancer is complex due to the involvement of infectious agents, gastric background and inflammatory response of the body. Improved diagnostic and treatment methods related to improving nutrition and development of the personalized medicine.

© 2013, Annals of Military and Health Sciences Research. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.


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