Urinary Tumor Necrosis Factor-Alpha a Good Indicator for Inflammatory Response in Pyelonephritis


Masoumeh Mohkam 1 , * , Sedigheh Rafiei Tabatabaei 1 , Fahimeh Asgarian 1 , Shahnaz Armin 1 , Alireza Fahimzad 1 , Mostafa Sharifian 1 , Reza Dalirani 1

1 Pediatric Infections Research Center, Shahid Beheshti University of Medical sciences, [email protected], IR Iran

How to Cite: Mohkam M, Rafiei Tabatabaei S, Asgarian F, Armin S, Fahimzad A, et al. Urinary Tumor Necrosis Factor-Alpha a Good Indicator for Inflammatory Response in Pyelonephritis, Arch Pediatr Infect Dis. Online ahead of Print ; 1(2):87-91. doi: 10.5812/pedinfect.9114.


Archives of Pediatric Infectious Diseases: 1 (2); 87-91
Published Online: July 15, 2013
Article Type: Research Article
Received: November 21, 2012
Accepted: January 1, 2013


Background: TNF-? is one of the most potent cytokines in proinflammatory reactions.

Objectives: This article contributes to evaluate the correlation between urinary TNF-? and inflammatory response markers in children with acute pyelonephritis.

Patients and Methods: This cross sectional study, was performed on children with acute pyelonephritis. Fresh random urine samples were obtained before treatment of pyelonephritis. Urine samples were tested for TNF-? and creatinine. We also evaluated our patients with routine biochemical studies.

Results: One hundred and twenty children with acute pyelonephritis were evaluated. Urinary TNF-?/Cr was 0.0051 0.00083 Pg/g creatinine. The authors found out a significant difference in urinary TNF-?/Cr between patients who have normal and abnormal levels of urine leukocytes, urine protein, urine culture, erythrocyte sedimentation rate and C- reactive protein. This study revealed a significant correlation between urinary TNF-alpha and urine WBC (r = 0.36, P value = 0.02), ESR (r = 0.75, P value = 0.03) and CRP (r = 0.58, P value = 0.02).

Conclusions: We concluded that urinary TNF-?/Cr might be a good indicator for inflammatory response in children with acute pyelonephritis.

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