Human Papillomavirus (HPV) Detection in Biopsies from Cervical Cancer Patients; A Population–Based Study from Iran


Mohammad Niakan 1 , * , Fariba Yarandi 2 , Maryam Entezar 2

1 Department of Microbiology, Faculty of Medicine, Shahed University, Tehran, IR Iran

2 Department of Gynecology and Obstetrics, Tehran University of Medical Sciences, Tehran, IR Iran

How to Cite: Niakan M, Yarandi F, Entezar M. Human Papillomavirus (HPV) Detection in Biopsies from Cervical Cancer Patients; A Population–Based Study from Iran, Arch Clin Infect Dis. 2009 ; 4(1):e93397.


Archives of Clinical Infectious Diseases: 4 (1); e93397
Published Online: January 30, 2009
Article Type: Brief Report
Received: May 12, 2019
Accepted: July 22, 2008


Background: Human papillomavirus (HPV) is associated with various benign and malignant lesions including genital condyloma and anogenital cancer. The presence of HPV-DNA was studied in archival biopsies of high- and intermediate-risk lesions for cervical carcinoma in women referred to Mirza hospital in Tehran.

Patients and methods: Totally, 105 Iranian archived biopsies collected during February and November 2006. HPVDNA was isolated from the biopsies and detected by means of consensus polymerase chain reaction (PCR) detecting a broad spectrum of genital HPV types.

Results: Totally, 26 samples (24.7%) were positive for oncogenic HPV-DNA. Risk of HPV infection was significantly higher in biopsies obtained from patients with confirmed squamous cell carcinoma (SCC) who started sexual activity more recently (≤4 years ago) when compared with those who started earlier (≥10 years ago). HPV-16 was more frequently detected in biopsies of younger women.

Conclusion: HPV was more frequently detected in young women. Our data confirm the usefulness of this method for detection of HPV in archival biopsies.



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