Vasectomy in Mouse Model Using Electrosurgery Machine

AUTHORS

N. Dadashpour Davachi 1 , *

1 Department of Research, Breeding and Production of Laboratory Animals, Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Karaj, Iran

How to Cite: Dadashpour Davachi N. Vasectomy in Mouse Model Using Electrosurgery Machine, Arch Razi Inst. 2019 ; 74(2):e95619. doi: 10.22092/ari.2019.126460.1345.

ARTICLE INFORMATION

Archives of Razi Institute: 74 (2); 191-195
Published Online: June 01, 2019
Article Type: Case Reports
Received: March 27, 2019
Accepted: June 01, 2019
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Abstract

Vasectomy in laboratory animals is a crucial step in the production of surrogate female mice. The surrogate mothers play a key role in successful embryo transfer, most important steps for the production of transgenic animal models, investigation of the preimplantation embryo development, and revitalization of cryopreserved strains. Abdominal and scrotal surgeries are common surgical procedures used in routine veterinary practice to produce vasectomized males. Two different surgical practice, namely electrosurgery and cold surgical practice, have been used as common techniques in operating rooms. Based on current knowledge, there is no published “technical note” as a detailed and step by step guideline to describe vasectomy using an electrosurgery machine (i.e., Bovie machine) in laboratory animal research and breeding facilities.The common problem during the laboratory animal surgery would be animal mortalities as a consequence of profound bleeding. The use of Bovie machine leads to the prevention of profound bleeding during the surgical practice.

© 2019, Archives of Razi Institute. Razi Vaccine and Serum Research Institute.

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