Impact of Phytobacterial Agent on the Toxic Damage to the Liver and Ileum of White Rats


S. S. Tarmakova 1 , S. Y. Sanzhieva 2 , * , E. S. Nikolaeva 3

1 Testing Laboratory Center, Buryat State Agricultural Academy named after V. R. Filippov, Ulan-Ude, Russia

2 Department of Ecology, Subsoil Use and Life Safety, East Siberia State University of Technologiy and Management, Ulan-Ude, Russia

3 LLC Small Innovative Enterprise "Bifimed", Ulan-Ude, Russia

How to Cite: Tarmakova S S, Sanzhieva S Y, Nikolaeva E S. Impact of Phytobacterial Agent on the Toxic Damage to the Liver and Ileum of White Rats, Arch Razi Inst. 2019 ; 74(3):e98582. doi: 10.22092/ari.2019.125886.1324.


Archives of Razi Institute: 74 (3); 287-294
Published Online: October 01, 2019
Article Type: Journal Article
Received: April 18, 2019
Accepted: May 28, 2019


Numerous pharmaceutical agents can induce adverse reactions in the human body, including toxicity to the liver and the inflammation of intestines. Therefore, nowadays one of the most urgent problems in modern medical science is the prevention and restoration of morphological and dysbiosis disorders caused by numerous medications. With this background in mind, we aimed to evaluate the efficacy of phytobacteria on toxic damage to the structure and function of the liver and ileum, as well as the composition of the large intestine microflora in white rats with intestinal dysbacteriosis due to carbon tetrachloride (CCl4) and ampicillin trihydrate. In order to prevent toxic damage to the liver and ileum of experimental animals, a phytobacterial agent was used. This test agent was composed of a mixture of commercial lactobacteria Lactobacillus helveticus with a water-soluble extract of thyme (Thymus Serpyllum L.) on a sterile milk basis. Our results showed that the introduction of phytobacterial agent led to reduced inflammation, accelerated regeneration of the ileum mucous membrane, and a positive effect on the damaged intestine. The phytobacterial agent increased the resistance of the body to potentially pathogenic microorganisms and toxic compounds by restoring the microflora of the large intestine. It was established that the phytobacterial remedy resulted in the normalization of the intestinal microflora of white rats, which had toxic damage to the liver and ileum caused by CCl4 and ampicillin trihydrate administration. Moreover, the usage of phytobacteria was correlated with improvement in the structure and function of the liver and ileum.

© 2019, Archives of Razi Institute. Razi Vaccine and Serum Research Institute.