Hepatitis C Virus Cryoglobulinemia and Non-Hodgkin Lymphoma


Zohreh Jadali 1 , * , Zohreh Jadali 1 , *

1 Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, IR Iran

Corresponding Authors:

How to Cite: Jadali Z, Jadali Z. Hepatitis C Virus Cryoglobulinemia and Non-Hodgkin Lymphoma, Hepat Mon. Online ahead of Print ; 12(2):85-91. doi: 10.5812/hepatmon.818.


Hepatitis Monthly: 12 (2); 85-91
Published Online: January 31, 2012
Article Type: Review Article
Received: December 17, 2011
Accepted: January 20, 2012


Context: On the strength of epidemiological data,biological studies, and clinical findings, hepatitis C virus appears to be involved in the pathogenesis of a proportion of patients with non-Hodgkin lymphoma and cryoglobulinemia.

Objectives: The aim of this paper is to review the published literature focused on the current knowledge concerning hepatitis C virus and its potential role in the production of non-Hodgkin lymphoma and cryoglobulinemia in susceptible individuals.

Evidence Acquisition: In this review, databases such as pubMed, embase, ISI, and Iranian databases including Iranmedex, and SID were searched.

Results: The results of this review indicate that HCV infection may be a likely cause of various B cell dysregulation disorders such as non-Hodgkin lymphoma and cryoglobulinemia.

Conclusion: Based on current findings, it has been hypothesized that NHL and cryoglobulinemia in HCV infection may have an immune-mediated pathogenesis. In HCV infected patients, we showed an elevated risk of these two diseases. These finding suggested a possible role for chronic hepatitis C in the pathogenesis of NHL and cryoglobulinemia.

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