Hepatitis B Immune Globulin in Liver Transplantation Prophylaxis: An Update


Payam Dindoost 1 , Seyed Mohammad Jazayeri 1 , Seyed Moayed Alavian ORCID 2 , *

1 Iranian Hepatitis Network, IR Iran

2 Research Center for Gastroenterology and Liver Diseases, Baqiyatallah University of Medical Sciences, [email protected], IR Iran

How to Cite: Dindoost P, Jazayeri S, Alavian S. Hepatitis B Immune Globulin in Liver Transplantation Prophylaxis: An Update, Hepat Mon. Online ahead of Print ; 12(3):168-176. doi: 10.5812/hepatmon.832.


Hepatitis Monthly: 12 (3); 168-176
Article Type: Review Article
Received: October 11, 2011
Accepted: January 29, 2012


Context: Liver transplantation is the best treatment option for end-stage liver disease following hepatitis B (HBV) infection. However, the high rate of recurrence of HBV infection following transplantation is a disadvantage of this option.
Evidence Acquisition: Over the past 2 decades, the gold standard of prophylactic treatment for the prevention of HBV re-infection following liver transplantation has been the administration of low- to high-dose hepatitis B immune globulin (HBIg) along with an antiviral agent to induce passive immunity.
Results: The effectiveness of HBIg in preventing the recurrence of HBV depends on the dosage, route of administration, and duration of HBIg treatment, and the viremic status at the time of transplantation. There is currently no consensus on a standardized recommendation for therapeutic options that include HBIg administration.
Conclusion: This review attempts to summarize the available data on the feasibility of such options. Most recent studies support the use of long-term combination therapy of HBIg and antiviral NAs (especially new agents).

  • Implication for health policy/practice/research/medical education:
    The article is suitable for hepatologist, internists, infectious specialists and liver transplantation departments.
  • Please cite this paper as:
    Dindoost P, Jazayeri SM, Alavian SM. Hepatitis B Immune Globulin and Liver Transplantation Prophylaxis: An UpDate. Hepat Mon.2012;12(3):168-76. DOI: 10.5812/hepatmon.832

Copyright © 2012 Kowsar Corp. All rights reserved.

© 0, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

Full Text

Full text is available in PDF