Paediatric Non-Alcoholic Fatty Liver Disease: Impact on Patients and Mothers’ Quality of Life


Luigi Mazzone 1 , * , Valentina Postorino 2 , Lavinia De Peppo 1 , Claudia Della Corte 3 , Giuseppe Lofino 3 , Lia Vassena 1 , Laura Fatta 1 , Marco Armando 1 , Giorgio Bedogni 3 , Stefano Vicari 1 , Valerio Nobili 3

1 Department of Neuroscience, Child Neuropsychiatry Unit, IRCCS Children's Hospital Bambino Gesù, Rome, Italy

2 Department of Dynamic and Clinical Psychology, University of Rome Sapienza, Rome, Italy

3 Hepato-Metabolic Diseases and Anesthesiology Unit, IRCCS Children's Hospital Bambino Gesù, Rome, Italy

How to Cite: Mazzone L, Postorino V, De Peppo L, Della Corte C, Lofino G, et al. Paediatric Non-Alcoholic Fatty Liver Disease: Impact on Patients and Mothers’ Quality of Life, Hepat Mon. 2013 ; 13(3):e93060. doi: 10.5812/hepatmon.7871.


Hepatitis Monthly: 13 (3); e93060
Published Online: March 12, 2013
Article Type: Research Article
Received: May 06, 2019
Accepted: December 09, 2012


Background: Non-alcoholic fatty liver disease (NAFLD) is one of the causes of fatty liver in adults and is currently the primary form of chronic liver disease in children and adolescents. However, the psychological outcome (i.e. the behavioural problems that can in turn be related to psychiatric conditions, like anxiety and mood disorders, or lower quality of life) in children and adolescents suffering of NAFLD has not been extensively explored in the literature.

Objectives: The present study aims at evaluating the emotional and behavioural profile in children suffering from NAFLD and the quality of life in their mothers.

Patients and Methods: A total of 57 children (18 females/39 males) with NAFLD were compared to 39 age-matched control children (25 females/14 males). All participants were submitted to the following psychological tools to assess behavior, mood, and anxiety: the Multidimensional Anxiety Scale for Children (MASC), the Child Behavior Checklist (CBCL), and the Children’s Depression Inventory (CDI). Moreover, the mothers of 40 NAFLD and 39 control children completed the World Health Organization Quality of Life-BREF (WHOQOL-BREF) questionnaire.

Results: NAFLD children scored significantly higher as compared to control children in MASC (P = 0.001) and CDI total (P < 0.001) scales. The CBCL also revealed significantly higher scores for NAFLD children in total problems (P = 0.046), internalizing symptoms (P = 0.000) and somatic complaints (P < 0.001). The WHOQOL-BREF revealed significantly lower scores for the mothers of NAFLD children in the overall perception of the quality of life (P < 0.001), and in the “relationships” domain (P = 0.023).

Conclusions: Increased emotional and behavioural problems were detected in children with NAFLD as compared to healthy control children, together with an overall decrease in their mothers’ quality of life. These results support the idea that these patients may benefit from a psychological intervention, ideally involving both children and parents, whose quality of life is likely negatively affected by this disease



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