Modulatory effect of aerobic training on some inflammatory profile indicators in obese females


Mojtaba Eizadi 1 , * , Laleh Behboudi 2

1 Department of Exercise Physiology, Saveh Branch, Islamic Azad University, Saveh, Iran.

2 Department of Exercise Physiology, Islamshahr Branch, Islamic Azad University, Tehran, Iran.

How to Cite: Eizadi M , Behboudi L . Modulatory effect of aerobic training on some inflammatory profile indicators in obese females, Hormozgan Med J. 2017 ; 21(4):e87361. doi: 10.29252/hmj.21.4.278.


Hormozgan Medical Journal: 21 (4); e87361
Published Online: December 18, 2017
Article Type: Research Article
Received: July 01, 2017
Accepted: December 18, 2017


Introduction: It is widely accepted that low grade systemic inflammation plays a key
role in obesity and related diseases and metabolic syndrome. The objective of this work
was to evaluate the effect of aerobic training intervention on CRP and IL-10 in adult obese
Methods: Thirty adult obese women (30≤BMI≤36) aged 30 to 40 years were
randomly assigned to exercise (3 months aerobic training, 3 time per week at 60-75% of
maximum heart rate, n=15) and control (no training, n=15). At baseline and after 3
months, anthropometrical indexes as well fasting serum IL-10 and CRP were assessed in
2 groups. Inter and intra-group changes were analyzed by independent and paired sample
T test. P<0.05 was considered statistically signigcant.
Results: After the 3 months of aerobic intervention, a significant decrease were observed in
BMI, abdominal circumference, body weight, body fat (%) and visceral fat of exercise
subjects (P<0.05). No significant difference was found in all variables between 2 groups at
baseline (P>0.05). Aerobic intervention resulted in significant increase in serum IL-10
(from 14.79±3.04 to 17.79±3 pg/ml, P=0.001) and decrease in CRP (from 5670±1971 to
3848±1092 ng/ml, P=0.002). All variables remained no change in control subjects
Conclusion: With emphasis on IL-10 and CRP, long-term aerobic training can be
considered as a anti-inflammatory treatment in sedentary obese females.

© 2017, Hormozgan Medical Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.



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