Investigating relationship between C- reactive protein and obesity in adults


Leila Jamshidi 1 , * , Simin Hojjatoleslami 1

1 Deprtment of Nursing , Hamadan Branch, Islamic Azad University, Hamadan, Iran.

How to Cite: Jamshidi L , Hojjatoleslami S . Investigating relationship between C- reactive protein and obesity in adults, Hormozgan Med J. 2016 ; 20(5):e87434.


Hormozgan Medical Journal: 20 (5); e87434
Published Online: January 16, 2017
Article Type: Research Article
Received: December 02, 2015
Accepted: January 16, 2017


Introduction: Association between plasma high-sensitivity C-reactive protein (CRP) concentrations and cardiovascular disease has been Investigated. C-reactive protein (CRP) is an acute phase reactant which is a marker of inflammation in the body. CRP is made by the liver in response to inflammatory cytokines such as interleukin-6 (IL-6) and tumor necrosis factor-α (TNFα). Adipose tissue is a major source of these inflammatory cytokines. The purpose of this study was, to examine differences in high-sensitivity C-reactive protein (hs-CRP) levels and body fatness.

Methods: A total of 260 adult healthy men and women were investigated in 2014. Body mass index (BMI) was measured for each participant. Blood samples were collected and CRP measurements were performed in the laboratory. Plasma CRP levels were measured by means of a colorimetric competitive ELISA. Data are expressed as mean±SD values. Relationship between obesity and CRP was analyzed by SPSS 20, and tested using χ2-test and logistic regression analysis.


Results: Subjects with elevated CRP had higher BMI and WC. For elevated CRP, subjects in the highest BMI quartile with subjects in the lowest BMI quartile. The result shows a relationship between CRP with BMI throughout the BMI spectrum. CRP levels were strongly correlated with BMI (P=0.0002).Levels of CRP also increased steadily across WC quartiles (P=0.0001). Waist circumference quartiles were also strongly associated with odds of elevated CRP. Women in the highest WC (91cm) and men in the highest WC (89cm) had an odd of elevated CRP.

Conclusion: Development and implementation of a global health strategy for prevention and control of non-communicable diseasesin recommended.



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