The effect of eight weeks of concurrent exercise on NT-proBNP and ferritin serum levels of Beta Thalassemia Major patients


Golnaz Arbab 1 , Marzieh Nikparvar 2 , * , Abbas Gaeini 3 , Seyed Alireza Sobhani 4

1 Assistant Professor Department of Sport Science , Islamic Azad University, Bandar Abbas Branch

2 Cardiovascular Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran

3 Professor Department of Physiology, Tehran University, Tehran, Iran.

4 Associate Professor Department of Phatology , Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

How to Cite: Arbab G, Nikparvar M, Gaeini A, Sobhani S A. The effect of eight weeks of concurrent exercise on NT-proBNP and ferritin serum levels of Beta Thalassemia Major patients, Hormozgan Med J. 2016 ; 20(1):e87906.


Hormozgan Medical Journal: 20 (1); e87906
Published Online: October 17, 2015
Article Type: Research Article
Received: September 27, 2015
Accepted: October 17, 2015


Introduction: Nowadays one of the most important problems of Thalassemia major patients is the additional load of iron and hemosiderosis, the most important consequence of which is deposited iron in myocardial tissue and the incidence of cardiomyopathy caused by hemochromatosis. The aim of this study was to determine the effect of concurrent (resistance-endurance) exercise on NT-pro BNP and ferritin serum levels of beta Thalassemia major patients.

Methods: Participants were 18 patients with Beta Thalassemia major (mean age 22.64±3.5) that voluntarily divided in two groups: experimental (n=9) and control group (n=9). The subjects of the experimental group attended the concurrent (Resistance- Endurance) exercise for eight weeks. Subjects' blood samples were taken before and after exercise protocol in order to measurement NT-proBNP and Ferritin Serum levels. The levels of NT-proBNP and Ferritin were measured by using an enzyme-linked Electro immuno assay (ELISA) kits. For data analysis the Repeated measures ANOVA, was used. All statistical analysis was performed by SPSS 19 software. The level of significance was considered P<0.05.

Results: The results indicated the reduction of NT-pro BNP after eight weeks of concurrent (resistance-endurance) exercise compared to the control group (P<0.05) and also the levels of Ferritin was significantly decreased comparing with the control group (P<0.05).

Conclusion: The reduction of NT-proBNP serum level and its natural range in the exercise protocol, can be a regulating response to hemodynamics cardiac pressure in patients under certain exercise conditions without any pathological importance and improved heart function. A significant reduction of ferritin serum indicates lower iron toxicity and it can be known as an effective factor in delayed cardiomyopathy that caused by excessive iron.



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