Infective endocarditis in intravenous drug users, evaluation of clinical and para-clinical presentation


Mehdi Besharat 1 , * , Farhad Abbasi 2 , Seyed Rahman Khoshhal 2

1 Assistant Professor Department of Infectious Disease, Infectious & Topical Medical Research Center, Shahid Beheshti Medical University, Tehran, Iran.

2 Infectious Disease Specialist, Bushehr University of Medical Sciences, Bushehr, Iran.

How to Cite: Besharat M, Abbasi F, Khoshhal S R. Infective endocarditis in intravenous drug users, evaluation of clinical and para-clinical presentation, Hormozgan Med J. 2011 ; 15(2):e88474.


Hormozgan Medical Journal: 15 (2); e88474
Published Online: February 16, 2011
Article Type: Research Article
Received: May 31, 2010
Accepted: February 16, 2011


Introduction: 60 percent of hospitalization causes of intravenous drug users are infection,
of which 5 to 15 percent of them due to endocorditis. Infective endocorditis is a common
infection among intravenous drug users and can cause high mortality and morbidity. This
study was conducted to evaluate clinical and para-clinical presentations of drug users.
Methods: In a descriptive study we evaluate 33 narcotic addicts with documented infective
endocarditis in two tertiary care hospitals in Tehran, Iran; Imam Hosein and Loghman
Hakim hospitals during 2002-2008. Demographic information, clinical manifestation,
radiologic, laboratory and echocardiographic data were evaluated. The data were analysed
using SPSS software.
Results: 82% of patients were in 20-40 year old age group. 52% of the cases were referred
to the hospital with main complain of fever and cough and 27% with pain and fever. Fever
was observed in 91% of the patients. Positive blood culture was observed in 9 cases and
negative blood culture in 14 cases. The most common involved valve was tricuspid.
Mortality rate was 45%.
Conclusion: Endocarditis should be considered in intravenous drug users when they
present with fever. Blood culture may be negative due to previous use of antibiotics and
poor technique of culture.



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