Positive association of H. pylori virulence Cag A, Vac A and UreAB genes with gastric disorders among Iranians


Shohreh Farshad 1 , * , Aziz Japoni 1 , Mehdi Kalani 1

1 Prof Alborzi Clinical Microbiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

How to Cite: Farshad S, Japoni A, Kalani M. Positive association of H. pylori virulence Cag A, Vac A and UreAB genes with gastric disorders among Iranians, Hormozgan Med J. 2009 ; 13(2):e88638.


Hormozgan Medical Journal: 13 (2); e88638
Published Online: January 11, 2009
Article Type: Research Article
Received: March 04, 2008
Accepted: January 11, 2009


Introduction: Helicobacter pylori organisms colonize approximately in half of the
world's humans but only a minority develops a clinically significant outcome, such as
gastritis, peptic ulcer disease or gastric cancer. It seems that bacterial virulence
factors and host's factors are involved in developing adverse clinical outcomes.
Methods: In this case-control study, association of virulence genes CagA, VacA and
UreAB of H.pylori with the development of different gastric disorders, polymerase
chain reaction was evaluated on H. pylori organisms isolated from biopsy samples of
stomach of 35 patients with ulcerative disease as cases, and 35 patients with no
ulcerative disease as control group. The results were analyzed using Fisher exact test
by SPSS Software.
Results: The difference between the groups was statistically significant (P<0.05)
only for VacA gene. According to the prevalence of the three genes under the
study, we detected 8 genotypes. The prevalence of phenotype CagA+ VacB+
UreAB+ was significantly higher in the patients with UD than that in the patients
with NUD (P<0.05).
Conclusion: The results suggest that subjects being infected by a H. pylori strain
with the genotype Cag+ VacA+ UreAB+ are likely associated with an increased risk
of acquiring an ulcerative disease.



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