Administration of aminophylline as a myocardial protective in CABG operation


Omid Assar 1 , * , Jamshid Bagheri 2 , Aflatoon Mehraeen 3 , Mohammad Jaebelli 2 , Mohammad Hossein Mandegar 4

1 Assistant Professor Department of Cardiac Surgery, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

2 Assistant Professor, Tehran University of Medical Sciences, Tehran, Iran.

3 Associate Professor Department of Anesthesia & Intensive Care, Tehran University of Medical Sciences, Tehran, Iran.

4 Department of Cardiac Surgery, Tehran University of Medical Sciences, Tehran, Iran.

How to Cite: Assar O, Bagheri J, Mehraeen A, Jaebelli M, Mandegar M H. Administration of aminophylline as a myocardial protective in CABG operation, Hormozgan Med J. 2010 ; 13(4):e88780.


Hormozgan Medical Journal: 13 (4); e88780
Published Online: October 31, 2009
Article Type: Research Article
Received: April 12, 2009
Accepted: October 31, 2009


Introduction: Myocardial protection is one of the most important determinants of
the result of CABG operation. The benefit of aminophylline has been proved in
addition to antegrade cardioplegia but has not been studied plus Antegrade and
retrograde cardioplegia. This study was designed to evaluate the effects of
aminophyliine as a cardioprotective agent for patients undergoing on-pump CABG
with antegrade and retrograde cardioplegia.
Methods: In this double-blinded randomized clinical trial, 40 patients were randomly
assigned to receive either IV aminophylline (5,g/kg) (n=20) or saline (n=20) before
anesthesia induction. Troponin T level was measured 30 minuets, 2 hours and 24 hours after
aortic clamping. For data analysis, t-test, chi-square and Mann-Whitney test was used.
Results: Troponin T level was significantly lower in aminophylline group 30 minutes
(P=0.03) and 2 hours (P=0.01) after aortic cross clamp. No difference was observed
with clinical Parameters.
Conclusion: Pretreatment with aminophylline reduces myocardial injury at sub-clinical
level, particularly to benefit the ante-retrograde cardioplegia alone.



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