Evaluation of endocrine dysfunction in thalassemia intermedia


Seyed Mehrdad Solati 1 , * , Masoumeh Forooz Asadi 2 , Mohsen Dehghani Zahedani 3 , Mohammadreza Evazi 1 , Manouchehr Kamali 4

1 Assistant Professor Department of Internal Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

2 Resident Department of Internal Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

3 Assistant Professor Department of Pathology, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

4 Resident Department of Anesthesia & Intensive Care, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

How to Cite: Solati S M, Forooz Asadi M, Dehghani Zahedani M, Evazi M, Kamali M. Evaluation of endocrine dysfunction in thalassemia intermedia, Hormozgan Med J. 2010 ; 13(4):e88783.


Hormozgan Medical Journal: 13 (4); e88783
Published Online: August 09, 2009
Article Type: Research Article
Received: June 13, 2009
Accepted: August 09, 2009


Introduction: Thalassemia is an inherited disease which leads to an imbalance of globinchain
synthesis and consequently, ineffective hematopoiesis. Iron deposits in many
important body organs, as endocrine organs due to blood transfusion or ineffective
hematopoiessis. The aim of the present study is to assess the endocrine disorders in the
patients with thalassemia intermedia referred to the thalassemia center of Bandar-Abbas,
Methods: Eighty-six patients with intermediate thalassemia attended the thalassemia center
of Bandar-Abbas were enrolled in a cross-sectional, descriptive-analytic study. They were
evaluated for demographic characteristics, past medical history, familial history and
physically examined for sexual maturity and thyroid gland weight assessment. Then blood
samples were taken to measure thyroid, parathyroid and sexual hormones. Fasting blood
glucose, magnesium and ferritin levels were checked and were analyzed by SPSS 16.0.
Results: There were 47 males (54.7%) and 39 females (45.3%). Frequency of
hypoparathyroidism was 18.6%, diabetes mellitus 8.1%, sub-clinical hypothyroidism
4.65%, hypo-phosphatemia 29.06%, and hypo-magnesemia was 1.16%. Delayed puberty
was found in 6.07% girls and, 4.7% boys. Primary amenorrhea was seen in 15.4% of
female cases. Moreover, there was not a significant difference in hemoglobin rate between
hypoparalhyaism and normal cases (P<0.05).
Conclusion: It's recommended to evaluate the patients' suffering from thalassemia
intermedia for diabetes mellitus, thyroid dysfunctions, parathyroid abnormality, and sexual
maturity routinely.



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