A comparative study between three topical treatments in patients with chronic suppurative otitis media


Mehdi Askari 1 , * , Marjan Farshadi 2

1 Assistant Professor Department of Surgery, Hormozgan University o Medical Sciences, Bandar Abbas, Iran.

2 General Practitioner, Hormozgan University o Medical Sciences, Bandar Abbas, Iran.

How to Cite: Askari M, Farshadi M. A comparative study between three topical treatments in patients with chronic suppurative otitis media, Hormozgan Med J. 2008 ; 12(2):e88945.


Hormozgan Medical Journal: 12 (2); e88945
Published Online: May 06, 2008
Article Type: Research Article
Received: June 20, 2007
Accepted: May 06, 2008


Introduction: Chronic suppurative otitis meida (CSOM) is a common ear disease
with potential intra and extracranial complications. The control of infection is
very important for prevention of its consequences. The aim of this study was to
compare three topical treatment modalities in patients with this disease.
Methods: A randomized clinical trial was performed on three groups of CSOM
patients with active otorrhea but without cholesteatoma, otomycosis or ear
polyps. They were treated with three different topical drug regimens: group I
(combined therapy, 61 patients) with acetic acid 1.5% solution and ciprofloxacin
0.3%; group II (acid therapy, 30 patients), with acetic acid 1.5% solution; and
group III (antibiotic therapy, 30 patients) with ciprofloxacin 0.3%. All patients
were followed weekly for 4 weeks and results compared with chi-square and
fisher tests.
Results: At the end of second week, the infection was controlled in 95.1% of
patients in group I, which was statistically greater than other two groups 50%,
73.3% respectively (p<0.0001). The response rate to topical therapy was also
more than other groups in group I patients, after one week of treatment
(p<0.001). In accordance with the ethical principles, 15 patients of group II and
8 patients of group III, with treatment failure, were also underwent combined
therapy, which 100% of these patients in the group II and 87.5% of them in the
group III, responded to treatment after two weeks.
Conclusion: According to our findings, the combined topical therapy with acetic
acid and ciprofloxacin is an effective and quick treatment method for control of
infection and otorrhea in patients with CSOM.



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