The results of six months follow up in patients with subclinical thyrotoxicosis


Seyed Mehrdad Solati dehkordi 1 , Ladan Ataei 2 , Mehdi Hedayati 2 , Fereydoun Azizi 2 , *

1 Assistant Professor Department of Internal Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

2 Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

How to Cite: Solati dehkordi S M, Ataei L, Hedayati M, Azizi F. The results of six months follow up in patients with subclinical thyrotoxicosis, Hormozgan Med J. 2008 ; 12(3):e88962.


Hormozgan Medical Journal: 12 (3); e88962
Published Online: February 04, 2008
Article Type: Research Article
Received: May 17, 2007
Accepted: February 04, 2008


Introduction: There is no definite treatment for subclinical hyperthyroidism which
is defined as suppressed TSH and normal T3 and T4 levels. In this study, patients
with subclinical hyperthyroidism were followed for 6 months without any medical
Methods: A total number of 285 patients of individuals who participated in Tehran
glucose and lipid study and had TSH≤0.3 mu/l and normal T3, T4 levels were
included. Second TSH measurement followed by a classic TRH measurement was
done in these subjects. Finally 20 subjects were included in the study according to
inclusion criteria (TSH≤0.3 mu/L and TSH rising lower than 1 mu/L after TRH test).
These subjects were followed for 6 months and hormone measurements were
performed at first, second and sixth months.
Results: The mean±SD of patients age was 48±13 years and 12 patients were
female. The mean of TSH level was 0.2±0.1 mu/l at presentation and T3 and T4
concentration were in normal range. A significant increase in mean of TSH level was
seen at first and second months (0.7±0.1 and 0.6±0.2 mu/l respectively; p<0.01) as
compared with the basic levels. The mean of TSH level was suppressed again in sixth
month (0.3±0.5 mu/L).
Conclusion: Normal TSH level in patients with subclinical hyperthyroidism cannot
commit the following euthyroidism in these patient.



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