The relationship between Indicators of plasma oxidative stress and photo aging

Introduction: Photo aging is significantly different from chronological aging in
both clinical and histological appearances. It has been suggested that oxidative
stress generated by ultraviolet radiation (UVR), leads to photo aging over a long
time period. This study was conducted to determine the relationship between the
indicators of plasma oxidative stress and photo damaged skin in patients who
referred to dermatology clinic in Birjand city.
Methods: In this case-control study, 33 patients with photo aging and 33 controls
(matched age and gender) were recruited after confirmation of the diagnosis by a
dermatologist. Mean time of sun exposure in patient and control groups was
measured separately. Plasma total antioxidant capacity, lipid per oxidation and
thiol groups' levels (as indicators of oxidative stress) were measured in case and
control groups. The collected data were analyzed using SPSS (ver.12) software.
Results: Mean time of sun exposure in case group (5.5 ± 2.1 hour per day) was
higher than control group (1.9 ± 1.2 hour per day) (p<0.001). Mean of plasma
lipid per oxidation levels in case group (3.4 ± 1.1 mmol/lit) was higher than
control group (2.80 ± 0.67 mmol/lit) (p<0.003). There was no significant
difference between mean of plasma total antioxidant capacity and mean of plasma
thiol groups in case and control groups.
Conclusion: The results of this study suggest that a relationship exists between
plasma lipid per oxidation levels and photo aging.