Cryoglobulinemia in patients with hepatitis C


Mohammadbagher Owlia 1 , * , Ramin Sami 2 , Ahmad Salimzadeh 3

1 Assistant Professor Department of Internal Medicine, Yazd, Iran.

2 Resident, Department of Internal Medicine, Yazd University of Medical Sciences, Yazd, Iran.

3 Assistant Professor Department of Internal Medicine, Tehran University of Medical Sciences, Tehran, Iran.

How to Cite: Owlia M, Sami R, Salimzadeh A. Cryoglobulinemia in patients with hepatitis C, Hormozgan Med J. 2007 ; 11(3):e89559.


Hormozgan Medical Journal: 11 (3); e89559
Published Online: November 12, 2006
Article Type: Research Article
Received: June 18, 2006
Accepted: November 12, 2006


Introduction: Cryoglobulinemia is a kind of immunoglobuline that form in various
conditions. These imunoglobulines, precipitate in cold environment and restore to
soluble state upon rewarming. Nowadays, strong association between cryoglobulines
and hepatitis C has been proposed.
Methods: This is a descriptive-analytic study in which we included all documented
cases of hepatitis C infection who referred to Shahid Sadoughi Hospital from May
2004 to December 2005. Their sera was assessed for cryoglobulines. Results were
analyzed by SPSS software and using Chi-square and t-test.
Results: Fifty patients entered the study while 8 persons (15%) were positive for
cryoglobulines. No statistically significant correlation was shown between positive
cryoglobulinemia and age, sex, mode of acquiring infection, liver enzyme titer,
HBs antigen and anti-HIV antibody.
Conclusion: Regarding the clinical significance of cryoglobolinemia in developing
different clinical syndromes, it is recommended to evaluate cryoglobulines in high
risk groups, especially patients with hepatitis C.



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