Erythrocyte pyruvate kinase deficiency among anemic individuals in Bandar Abbas, Iran


Ahmadagha Negahi 1 , * , Maryam Ashrafi 2

1 Assistant Professor, Department of Internal Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

2 General Practitioner.

How to Cite: Negahi A, Ashrafi M. Erythrocyte pyruvate kinase deficiency among anemic individuals in Bandar Abbas, Iran, Hormozgan Med J. 2006 ; 10(1):e89743.


Hormozgan Medical Journal: 10 (1); e89743
Published Online: December 11, 2005
Article Type: Research Article
Received: December 28, 2004
Accepted: December 11, 2005


Introduction: Thalassemia is an important disease in East Mediterranean area
and especially in Iran. The disease is more prevalent in Hormozgan province
(South of Iran) than other parts of the country. Thalassemia has several
complications including convulsion. In thalassemia patients, hypocalcaemia was
correlated with hypoparathyroidism and is accompanied with convulsions. This
study’s aim was to determine the serum levels of calcium and phosphorus in
thalassemic patients with a prior history of convulsion.
Methods: In this cross-sectional study, 607 major thalassemia, thalassemia
intermidia and sickle thalassemia patients referred to thalassemia center of Bandar
Abbas were sorted according to type of thalassemia, demographic data,
presentation, and convulsion history. Level of calcium and phosphorus were
detected with standard lab analysis methods. Fisher exact test and Chi-Square test
were used to analyze the data.
Results: According to our findings, among 607 identified cases aged 12.2±6.6
years, 46.1 percent (280 cases) were female and 53.9 percent (327 cases) were
male. Prevalence of hypocalcaemia was 26.5% (95% CI, 23.1%-30.3%),
prevalence of hyperphosphatemia was 37.4% and the prevalence of convulsion
history was 9.9%. In spite of hypocalcaemia being more prevalent in thalassemia
patients with convulsion, there was no significant difference between
hypocalcemia in patients with prior history of convulsion and patients without
Conclusion: This study shows indirect relation between prevalence of
hypocalcaemia and hyperphosphatemia in thalassemic patients with or without
convulsion and direct correlation between severity of thalassemic and convulsion



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