Prevalence of hepatitis C resulted from blood transfusion in major thalassemia patients in Semnan, Damghan and Garmsar (2002)


Mohammad Faranoush 1 , * , Raheb GHorbani 2 , Mohammad Esmaeil Amin Bidokhtii 1 , Parvaneh Vosoogh 3 , Mojtaba Malek 3 , Mohammad Sadegh Yazdiha 1

1 Assistant Professors Departments of Pediatrics, Semnan University of Medical Sciences, Semnan, Iran.

2 Assistant Professeor, Department of Community Medicine, Semnan University of Medical Sciences, Semnan, Iran.

3 Assistant Professor, Department of Internal Medicine, Iran University of Medical Sciences, Tehran, Iran.

How to Cite: Faranoush M, GHorbani R, Amin Bidokhtii M E, Vosoogh P, Malek M, et al. Prevalence of hepatitis C resulted from blood transfusion in major thalassemia patients in Semnan, Damghan and Garmsar (2002), Hormozgan Med J. 2006 ; 10(1):e89791.


Hormozgan Medical Journal: 10 (1); e89791
Published Online: November 06, 2005
Article Type: Research Article
Received: November 06, 2004
Accepted: November 06, 2005


Introduction: Hepatitis C is one of the most important liver diseases in the
world. The most common cause of hepatitis is blood transfusion. Children with
thalassemia who receive frequent blood transfusions are at high risk of hepatitis
C virus (HCV) infection. Thus their diagnosis and treatment on them causes
reduction of next consequences.
Methods: In this descriptive study all the patients with major thalassemia (630
cases) in Semnan, Damaghan and Garmsar were investigated. Five cc blood was
taken 2 weeks after the last blood transfusion. All the blood samples were sent to
the blood transfusion organization regarding the cold chain. In the first stage
antibody against HCV was checked by ELISA method, and in the second stage all
the patients with positive anti-HCV antibodies in the first stage were re-sampled
again and re-checked using ELISA. Being positive in to stages indicated that they
had hepatitis C. In the third stage all positive samples with anti-HCV antibodies
were re-checked via PCR to determine the RNA of the virus. The mentioned
sample was taken for anti-HCV antibody test and HCV-RNA PCR. Other
required data were obtained from their records. The results were presented using
descriptive methods.
Results: The mean age of patients was 11.8 (SD=4.7). 39.7% of the patients had
positive anti HCV antibodies and in 60% of those who had positive anti HCV
antibodies, the PCR was also positive. 31.7% of the patients had first-degree
family history of major thalassemia and in 50% of them, anti HCV antibodies and
PCR were positive. But in those who didn’t have a family history of major
thalassemia, 34.95% had positive antibodies and 33.3% had positive PCR.
Conclusion: Due to increase of hepatitis C in thalassemia patients, performing
specific tests, frequent follow up, and prompt treatment is necessary for them.
Furthermore, more attention is required to prevent hepatitis C infection in
thalassemia cases.



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