Vasorelaxant effect of aerial part of Marrubium vulgare in aorta of male diabetic rat


Mehrdad Roghani 1 , * , Tourandokht Bloochnejad Mojarad 2 , Farshad Roghani 3 , Mohsen Khalili 1

1 Assistant Professor, Department of Physiology, Shahed University, Tehran, Iran.

2 Associate Professor, Department of Physiology, Iran University of Medical Sciences, Tehran, Iran.

3 Assistant Professor, Department of Internal Medicine, Shahre Kord University of Medical Sciences, Shahr Kord, Iran.

How to Cite: Roghani M, Bloochnejad Mojarad T, Roghani F, Khalili M. Vasorelaxant effect of aerial part of Marrubium vulgare in aorta of male diabetic rat, Hormozgan Med J. 2006 ; 10(2):e89800.


Hormozgan Medical Journal: 10 (2); e89800
Published Online: July 05, 2006
Article Type: Research Article
Received: September 06, 2005
Accepted: July 05, 2006


Introduction: Considering the higher incidence of atherosclerosis and
cardiovascular disorders in diabetes mellitus and the role of vasorelaxation
disturbance in the development of these complications, this study was conducted
to evaluate the effect of two-month oral administration of Marrubium vulgare
(MV) on the vasorelaxation response of isolated aorta in experimental model of
diabetes mellitus in rats.
Methods: In this experimental study, 32 male Wistar rats were randomly divided
into four groups: control, MV-treated control, diabetic, and MV-treated diabetic
groups. For induction of diabetes, streptozotcin (STZ) was intraperitoneally
administered (60mg/kg). MV-treated groups received MV mixed with standard
pelleted food at a weight ratio of 1/15. After 2 months, relaxation response of
KCI-and noradrenaline-precontracted aortic rings was determined after addition
of acetylcholine using isolated tissue setup.
Results: Comparing to one week before test serum glucose level showed a
significant increase in diabetic group at 4th and 8th weeks (P<0.001), while this
increase was not observed in MV-treated diabetic group. In addition, the latter
group showed a higher vasorelaxation in KCI-and noradrenaline-precontracted
rings (P<0.05) as compared to diabetic group. Meanwhile, there was no
significant difference between control and MV-treated control groups regarding
relaxation response.
Conclusion: It can be concluded that oral administration of MV for 2 months
could improve the vasorelaxation response of the vascular system and this may
prevent the development of hypertension in diabetic rats.



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