The role of interleukin on uterine endometrium, placenta and embryonic implantation


Soghra Bahmanpour 1 , *

1 Associate Professor Department of Anatomy, Shiraz University of Medical Sciences, Shiraz, Iran.

How to Cite: Bahmanpour S. The role of interleukin on uterine endometrium, placenta and embryonic implantation, Hormozgan Med J. 2007 ; 10(4):e90150.


Hormozgan Medical Journal: 10 (4); e90150
Published Online: July 05, 2006
Article Type: Review Article
Received: July 23, 2005
Accepted: July 05, 2006


Introduction: The polypeptide cytokine interleukin-1 is found in all body tissues and
plays its role in inflammatory changes. Interleukin-1 is known as alarm cytokine in
defense mechanism, particularly immunological responses. The interleukin receptor
is present in different tissues and in endometrial epithelium and its antagonist will be
increased during preimplantation period, therefore it participates in endometrial
preparation for embryonic receptivity. Therefore blocking of interleukin receptor
inhibits the embryonic implantation. An increase in the interleukin system is observed
during menstrual period especially within leuteal phase.
Knowledge of the interleukin system and its functional roles as a key molecular
factor in implantation is important. The pregnancy success or failure is related to
suitable or unsuitable interaction between blastocyst and endometrium, which is
affected by paracrine cytokine control. The cytokine 1 has two types as æ and β.
the latter is found in the placenta. Its antagonist receptor inhibits the implantation
trough interleukin receptor-antagonist complex formation. Interleukin receptor
antagonist complex formation can inhibit the interleukin physiological activity
without any cytotoxic effects.
The interleukin system reaches the highest level of activity during the 4th and 5th
days of pregnancy. These findings confirm that blocking interleukin leads to
inhibition of blastocyst implantation. It can be concluded that he interaction,
secretion, receptivity and other interleukin-related factors have key roles in the
implantation and relationship between the endometrium and embryo.



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