Comparison between topical and systemic treatment of vulvovaginal candidiasis


Aviz Rahimzadeh 1 , * , Ezatallah Rahimi 2

1 Assistant professor, Department of Obstetric & Gynecology, Kordestan University of Medical Sciences, Sanandaj, Iran.

2 Internal Medicine Resident, Oromieh University of Medical Sciences.

How to Cite: Rahimzadeh A, Rahimi E. Comparison between topical and systemic treatment of vulvovaginal candidiasis, Hormozgan Med J. 2005 ; 9(2):e90363.


Hormozgan Medical Journal: 9 (2); e90363
Published Online: July 30, 2005
Article Type: Research Article
Received: January 01, 2005
Accepted: July 30, 2005


Introduction: Vulvovaginal condidiasis is a common problem faced by
physicians in their outpatient department. The objective of the study was to
compare the efficacy of topical versus systemic treatment of systematic vaginal
candidiasis in outpatient setting of women who came to the Beasat gynecologic
clinic in Sanandaj.
Methods: In this randomized clinical trial, Forty five women with diagnosis of
vulvovaginal candidiasis were randomized into three equal groups getting
intravaginal topical clotrimazole daily for 7 days (group 1), Fluconazple (150 mg)
as one time dose (group 2) and Ketoconazole (200 mg) twice daily for seven days
(group 3). The women were reevaluated after 1 week when they were called for
follow up. Data were analyzed using Fisher and Chi-square statistical tests.
Results: There was significant improvement in all three groups of treatment.
Cure rate was highest in group 1 (84.6%) followed by group 3 (69.2%) and
group 2 (46.7%). But the difference was not statistically significant.
Conclusion: All the three treatment group were found to equally effective in the
management of vulvovaginal candidiasis. Single dose Fluconazole seems to be the
best for its ease of use.



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