C-Reactive protein changes in orthopedic surgical operations


Alireza Saied 1 , * , Aliya Ayatollahi Mousavi 2

1 Assistant Professor, Department of Orthopedic, Kerman University of Medical Sciences, Kerman, Iran.

2 General Practitioner.

How to Cite: Saied A, Ayatollahi Mousavi A. C-Reactive protein changes in orthopedic surgical operations, Hormozgan Med J. 2005 ; 9(3):e90374.


Hormozgan Medical Journal: 9 (3); e90374
Published Online: August 28, 2005
Article Type: Research Article
Received: May 10, 2004
Accepted: August 28, 2005


Introduction: CRP (C-Reactive protein), an acute phase reactant, is considered
as an indicator of inflammation and its measurement has been used as an early
indicator of infection. This study was performed in order to examine the natural
changes in CRP in orthopedic surgical operations related to long bone fractures in
Shahid Mohammadi Hospital, Bandar Abbas, Iran.
Methods: 54 patients were enrolled in this descriptional study, of which
ultimately 39 completed the study period. In all of the patients, CRP was checked
serially until it became negative. T-test and analysis of variance was used for
statistical analysis and P<0.05 was considered significant.
Results: In all of the patients, the peak CRP elevation was observed on the
second postoperative day (48 Hours) and in all of the uncomplicated cases, CRP
returned to normal within 3 weeks. The difference between CRP rise in upper
and lower limbs was statistically significant (P<0.002).
Conclusion: It seems that a high CRP titer after 3 weeks, in a patient who has
undergone surgery for a single long bone fracture, is good evidence of
complication occurrence, especially an infection.



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