Comparison of Fennel and Chamomile extract and placebo in treatment of premenstrual syndrome and dysmenorrheal


Maryam Yazdani 1 , * , Mehdi Shahriari 2 , Bahareh Hamedi 3

1 Departments of Obstetric & Gynecology, Shiraz University of Medical Sciences, Shiraz, Iran.

2 Pediatrics, Shiraz University of Medical Sciences, Shiraz, Iran.

3 General Physicion.

How to Cite: Yazdani M, Shahriari M, Hamedi B. Comparison of Fennel and Chamomile extract and placebo in treatment of premenstrual syndrome and dysmenorrheal, Hormozgan Med J. 2004 ; 8(1):e90600.


Hormozgan Medical Journal: 8 (1); e90600
Published Online: March 13, 2004
Article Type: Research Article
Received: September 29, 2003
Accepted: March 13, 2004


Introduction: Premenstrual syndrome (PMS) and dysmenorrheal are experienced
by majority of women in reproductive age and in 1% of the women it is severe
enough to interfere with social interaction and work performance. Many
investigations on treatment of this problem, in particular on treatment with
chemical drugs, have been carried out. The aim in this study is to find whether or
not herbaceous drugs such as Fennel and Chamomile, which are generally used in
traditional medicine, are effective in treatment of dysmenorrheal and PMS.
Methods: In this clinical trial study, 60 women over 16 years of age with a
convincing history of premenstrual syndrome were randomly selected and their
PMS and dysmenorrheal experiences were investigated in 5 menstruation cycles.
During the 1st cycle, they didn’t take any medication, during the 2nd and 3rd cycles
they took Fennel extract and during 4th and 5th cycles, they took Chamomile
extract. After each cycle they completed a questionnaire containing 16 PMS
symptoms. Friedman statistical test was used to compare the results from
different cycles. P<0.05 was considered significant.
Results: Based on the results, there was a significant difference between severity
of symptoms in the control cycle, and other cycles in 3 of the 16 PMS symptoms
(p<0.05). These three symptoms were pelvic and abdominal pains, fatigue and
lethargy, depression and anger. As for other symptoms, the severity in the Fennel
and Chamomile herbal drugs cycles was less than that of the control cycle, but
this difference was not statistically significant.
Conclusion: According to this study, Fennel and Chamomile are effective in
reducing some PMS disorders. Fennel is more effective in pelvic and abdominal
pain and depression but Chamomile is more effective in fatigue and lethargy.



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