Association between myasthenia gravis and HLA antigens in patients referred to Shafa hospital, Kerman


Mohammad Ali Shafa 1 , Alireza Vakilian 2 , * , Jafar Ahmadi Kohanali 3

1 Department of Internal Medicine, Kerman University of Medical Sciences, Kerman, Iran.

2 Neurologist, Kerman, Iran.

3 General Physician.

How to Cite: Shafa M A, Vakilian A, Ahmadi Kohanali J. Association between myasthenia gravis and HLA antigens in patients referred to Shafa hospital, Kerman, Hormozgan Med J. 2004 ; 8(3):e90702.


Hormozgan Medical Journal: 8 (3); e90702
Published Online: September 05, 2004
Article Type: Research Article
Received: February 29, 2004
Accepted: September 05, 2004


Introduction: Myasthenia gravis is a disease of neuromuscular junction. Familial
cases have been reported. Relation between myasthenia gravis and HLA antigens
has been seen in many studies from different parts of the world. The aim of this
study is determination of association between HLA class I haplotypes and
myasthenia gravis in Kerman province.
Methods: In this cross sectional study 44 myasthenic patients and 100 healthy
control subjects were studied. Microlymphocytotoxicity method was used for
HLA typing. Statistical analysis was done using X2 and Fisher exact tests.
Results: Prevalence of HLA-A9, A26, A11 in myasthenic patients were
significantly lower than healthy control group. Where as, frequency of HLA-B8
in patients group was significantly higher than healthy control group. There was
no statistically significant difference between the two groups in other HLA class I
Conclusion: Myasthenia gravis is associated with some types of HLA haplotypes.
This association can be variable in different parts of the world and in various
races. In Kerman the results of this study indicate that the disease is positively
associated with HLA B8 and negatively associated with HLA-A9, A11 and A26.



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