Her2/neu Expression in Wilms' Tumor and Correlation With Histopathologic Findings


Mashaallah Babashahi 1 , Mitra Mehrazma 2 , * , Seyed Javad Nasiri 3 , Farid Azizi Jalilian 4 , Mostafa Rezaei-Tavirani 5

1 Dept. of Pathology, Iran University of Medical Sciences, Tehran, Iran

2 Oncopathology Research Center, Iran University of Medical Sciences, Tehran, Iran

3 Dept. of Pathology , Ali-Asghar Children Hospital, Iran University of Medical Sciences, Tehran, Iran

4 Dept. of Medical Microbiology, Ilam University of Medical Sciences, Ilam, Iran

5 Proteomics Research Center, ShahidBeheshti University of Medical Sciences, Tehran, Iran

How to Cite: Babashahi M, Mehrazma M , Nasiri S J, Azizi Jalilian F, Rezaei-Tavirani M. Her2/neu Expression in Wilms' Tumor and Correlation With Histopathologic Findings, Int J Cancer Manag. 2013 ; 6(3):e80429.


International Journal of Cancer Management: 6 (3); e80429
Published Online: September 30, 2013
Article Type: Research Article
Received: January 02, 2013
Accepted: February 14, 2013


Background: Wilms' tumor is an emberyonal tumor arising from remnants of immature renal tissue. Her2/neu is an onco-protein which mediates cellular proliferation, differentiation and survival.

Methods: In the current study, we analyzed Her2/neu expression in 40 Wilms' tumors. The clinico-demographic data of 40 patients with Wilms' tumor were retrieved. Immunohistochemical staining for HER2/neu was performed. Her2/neuimmunoreactivity was evaluated by Canadian Consensus 2007 scoring system.

Results: Among the 38 specimens with epithelial component, 68.5% were positive for Her2/neu, whereas there was immunoreactivity in 37% of 38 blastemal, and 12% of 31 stromal components. The Her2/neu expression was significantly higher in early stages (81.5%) than in advanced stages (36.4%) in epithelial component, but not in other components.

Conclusion: This study suggested that Her2/neuexpression is associated with epithelial cell differentiation accompanied by lower stages of tumor. No significant relationship was found between Her2/neu positivity and tumor size and patient's age and gender.


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