Family History as a Risk for Upper Gastrointestinal Tract Cancer: A Case Control Study


A Safaee 1 , Bijan Moghimi-Dehkordi 1 , * , SR Fatemi 1 , E Maserat 1 , F Ghafarnejad 1 , MR Zali 1

1 Research Center of Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Science, Tehran, Iran

How to Cite: Safaee A, Moghimi-Dehkordi B , Fatemi S, Maserat E, Ghafarnejad F, et al. Family History as a Risk for Upper Gastrointestinal Tract Cancer: A Case Control Study, Int J Cancer Manag. 2011 ; 4(3):e80741.


International Journal of Cancer Management: 4 (3); e80741
Published Online: September 30, 2011
Article Type: Research Article
Received: January 03, 2011
Accepted: June 20, 2011


Background: Although, family history of cancer is an important risk factor for upper gastrointestinal cancers development, but limited information is available on the upper gastrointestinal cancers associated with family history in Iran. The purpose of this study was to define upper gastrointestinal cancers risk associated with family history of cancer.

Methods: This study was conducted as a case control study. A total number of 1,010 cases of upper gastrointestinal cancer and 1,010 healthy controls were recruited. For family history of cancer, questions were asked about any malignant tumor in first and second degree relatives. Adjusted odds ratio estimates for the association family history and upper gastrointestinal cancers risk and corresponding 95% confidence intervals were obtained.

Results: A family history of any malignant tumor in relatives was associated with 1.3 fold increased risks of upper gastrointestinal cancers. A first-degree family history of esophageal and gastric cancer was significantly associated with upper gastrointestinal cancers development, with an adjusted OR of 4.7(CI 95%: 2.6- 8.4).

Conclusion: Our findings suggested that risk for upper gastrointestinal cancers increases among individuals with family history of cancer. Therefore, appropriate screening strategies especially in relatives of patients should be considered to prevent and control of disease.


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