Premature ovarian failure (POF) is characterized by hypergonadotropic amenorrhea, before the age of 40, for which the Inhibin α-subunit (INHα) gene is proposed as a candidate gene, due to its role in negative feedback control of FSH. In this study we aimed at demonstrating the candidate mutation as a gene variation associated with POF in Iranian population. Materials & Methods: Using DNA sequencing, DNA samples of 24 women with POF and 24 controls, aged below 40 years, were screened for mutations in the Inhibin gene. Results: The 769G→A mutation in exon 2 of the Inhibin-α gene was found in four out of 24 idi-opathic POF patients. Conclusion: The results obtained in this study have shown that this variation is more frequent in patients with POF than in normal fertile pop-ulations of Iran.

"/> Premature ovarian failure (POF) is characterized by hypergonadotropic amenorrhea, before the age of 40, for which the Inhibin α-subunit (INHα) gene is proposed as a candidate gene, due to its role in negative feedback control of FSH. In this study we aimed at demonstrating the candidate mutation as a gene variation associated with POF in Iranian population. Materials & Methods: Using DNA sequencing, DNA samples of 24 women with POF and 24 controls, aged below 40 years, were screened for mutations in the Inhibin gene. Results: The 769G→A mutation in exon 2 of the Inhibin-α gene was found in four out of 24 idi-opathic POF patients. Conclusion: The results obtained in this study have shown that this variation is more frequent in patients with POF than in normal fertile pop-ulations of Iran.

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Existence of Inhibin ?-Subunit Gene Mutation in a Population of Iranian Women with Premature Ovarian Failure

AUTHORS

M Fallahian 1 , F Pouresmaeili 2 , * , F Azizi 1 , M R Zali 3 , E M Samani 1 , P Kharaziha 3

1 Department of Obstetrics and Gynecology,Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, I.R.Iran

2 Department of Genetics, and Infertility & Reproductive Health Research Center(IRHRC), Taleghani Hospital, Shahid Beheshti University of Medical Sciences, [email protected], I.R.Iran

3 Research center for gastroenterology and liver diseases, Taleghani Hospital, Shahid Beheshti University of MedicalmSciences, IR.Iran

How to Cite: Fallahian M, Pouresmaeili F, Azizi F, Zali M, Samani E, et al. Existence of Inhibin ?-Subunit Gene Mutation in a Population of Iranian Women with Premature Ovarian Failure, Int J Endocrinol Metab. Online ahead of Print ; 7(2):67-71.

ARTICLE INFORMATION

International Journal of Endocrinology and Metabolism: 7 (2); 67-71
Article Type: Original Article
Received: January 1, 2008
Accepted: May 20, 2009
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Abstract

Premature ovarian failure (POF) is characterized by hypergonadotropic amenorrhea, before the age of 40, for which the Inhibin α-subunit (INHα) gene is proposed as a candidate gene, due to its role in negative feedback control of FSH. In this study we aimed at demonstrating the candidate mutation as a gene variation associated with POF in Iranian population. Materials & Methods: Using DNA sequencing, DNA samples of 24 women with POF and 24 controls, aged below 40 years, were screened for mutations in the Inhibin gene. Results: The 769G→A mutation in exon 2 of the Inhibin-α gene was found in four out of 24 idi-opathic POF patients. Conclusion: The results obtained in this study have shown that this variation is more frequent in patients with POF than in normal fertile pop-ulations of Iran.

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