Disturbances of thyroid hormones metabolism and morphology are common in ESRD (End Stage Renal Disease) but data available shows discrepancies re-garding the post transplantation status of kidney re-cipients . The aim of this study was to assess thyroid function and morphology after kidney transplanta-tion surgery. Materials and Methods: Thirty-two kidney recepient patients, without previous history of thyroid disor-ders, were enrolled. Serum levels of creatinine TT3, TT4, RT3U, TSH and thyroid staging were obtained and echogenicity were determined by ultrasonogra-phy one week before and 1, 3 and 6 months after kidney transplant surgery. Results: Thirty-two patients (22 males, 10 females) with mean±SD of age 38.2±12.6 years were evalu-ated. TT3, TT4 and RT3U levels significantly in-creased by improvement of graft function (p< 0.05) but in 7 patients with delayed graft function those values remained at lower levels. No cases with hy-perthyroidism or hypothyroidism were detected. Thyroid volume decreased and echogenicity in-creased after transplantation (p<0.05). Six patients had thyroid nodules and cysts before surgery and 2 new cysts were detected after surgery. There was no relationship between age, sex, type and duration of dialysis and thyroid function after transplantation. Conclusion: This study reveals a clear correlation be-tween thyroid function and morphology (volume and echogenicity) and improvement of kidney func-tion after transplantation; long-term follow-up is however required for evaluation of occurrence of thyroid nodules and malignancies following trans-plantation.

"/> Disturbances of thyroid hormones metabolism and morphology are common in ESRD (End Stage Renal Disease) but data available shows discrepancies re-garding the post transplantation status of kidney re-cipients . The aim of this study was to assess thyroid function and morphology after kidney transplanta-tion surgery. Materials and Methods: Thirty-two kidney recepient patients, without previous history of thyroid disor-ders, were enrolled. Serum levels of creatinine TT3, TT4, RT3U, TSH and thyroid staging were obtained and echogenicity were determined by ultrasonogra-phy one week before and 1, 3 and 6 months after kidney transplant surgery. Results: Thirty-two patients (22 males, 10 females) with mean±SD of age 38.2±12.6 years were evalu-ated. TT3, TT4 and RT3U levels significantly in-creased by improvement of graft function (p< 0.05) but in 7 patients with delayed graft function those values remained at lower levels. No cases with hy-perthyroidism or hypothyroidism were detected. Thyroid volume decreased and echogenicity in-creased after transplantation (p<0.05). Six patients had thyroid nodules and cysts before surgery and 2 new cysts were detected after surgery. There was no relationship between age, sex, type and duration of dialysis and thyroid function after transplantation. Conclusion: This study reveals a clear correlation be-tween thyroid function and morphology (volume and echogenicity) and improvement of kidney func-tion after transplantation; long-term follow-up is however required for evaluation of occurrence of thyroid nodules and malignancies following trans-plantation.

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Thyroid Function and Volume Changes in Patients with End Stage Renal Disease, Before and After Kidney Transplantation

AUTHORS

F Sarvghadi ORCID 1 , * , S Khalili 2 , A Tara 2 , J Najafi 3 , A Aliasgari 2 , AS Kolahi 2

1 Department of Internal Medicine, Loghman Hakim General Hospital, [email protected], I.R.Iran

2 Department of Internal Medicine, Loghman Hakim General Hospital, I.R.Iran

3 Department of Radiology, Shaheed Modarres Genetal Hospital,Tehran, I.R.Iran

How to Cite: Sarvghadi F, Khalili S, Tara A, Najafi J, Aliasgari A, et al. Thyroid Function and Volume Changes in Patients with End Stage Renal Disease, Before and After Kidney Transplantation , Int J Endocrinol Metab. Online ahead of Print ; 6(3):141-148.

ARTICLE INFORMATION

International Journal of Endocrinology and Metabolism: 6 (3); 141-148
Article Type: Original Article
Received: June 14, 2007
Accepted: August 13, 2007
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Abstract

Disturbances of thyroid hormones metabolism and morphology are common in ESRD (End Stage Renal Disease) but data available shows discrepancies re-garding the post transplantation status of kidney re-cipients . The aim of this study was to assess thyroid function and morphology after kidney transplanta-tion surgery. Materials and Methods: Thirty-two kidney recepient patients, without previous history of thyroid disor-ders, were enrolled. Serum levels of creatinine TT3, TT4, RT3U, TSH and thyroid staging were obtained and echogenicity were determined by ultrasonogra-phy one week before and 1, 3 and 6 months after kidney transplant surgery. Results: Thirty-two patients (22 males, 10 females) with mean±SD of age 38.2±12.6 years were evalu-ated. TT3, TT4 and RT3U levels significantly in-creased by improvement of graft function (p< 0.05) but in 7 patients with delayed graft function those values remained at lower levels. No cases with hy-perthyroidism or hypothyroidism were detected. Thyroid volume decreased and echogenicity in-creased after transplantation (p<0.05). Six patients had thyroid nodules and cysts before surgery and 2 new cysts were detected after surgery. There was no relationship between age, sex, type and duration of dialysis and thyroid function after transplantation. Conclusion: This study reveals a clear correlation be-tween thyroid function and morphology (volume and echogenicity) and improvement of kidney func-tion after transplantation; long-term follow-up is however required for evaluation of occurrence of thyroid nodules and malignancies following trans-plantation.

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