Relation Between Pre-and Post-Dexamethasone Test Cortisol Values in Cushing's Disease

AUTHORS

Laurberg P e , *

How to Cite: P L. Relation Between Pre-and Post-Dexamethasone Test Cortisol Values in Cushing's Disease, Int J Endocrinol Metab. Online ahead of Print ; 2(2):74-77.

ARTICLE INFORMATION

International Journal of Endocrinology and Metabolism: 2 (2); 74-77
Published Online: January 1, 2004
Article Type: Original Article
READ FULL TEXT

Abstract

Introduction: The dexamethasone test has been widely used for diagnosing hypercortisolism.

Materials and Methods: We assessed the relationship between the basal and suppressed cortisol values in urine and plasma during a low-dose dexamethasone test in patients with proved Cushing's disease.

Results: A statistically highly significant correlation was found (for urine cortisol: r = 0.66, P <0.0001; for plasma cortisol: r = 0.94, P <0.003).

Conclusions: These findings imply that the lower the pretest cortisol values, the lower are the suppressed values. In patients with suspected Cushing's syndrome and only slightly elevated cortisol excretjon or low plasma concentration, the outcome might easily be considered normal. This point is particularly pertinent when assessing the post-treatment status.

Full Text

Full text is available in PDF

© 2004, International Journal of Endocrinology and Metabolism. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
COMMENTS

LEAVE A COMMENT HERE: