Effects of Purified Omega-3 Fatty Acids on Serum Lipoproteins and Malondialdehyde in Postmenopausal Fat Women Receiving Hormone Replacement Therapy

AUTHORS

Shidfar F 1 , * , Keshavarz A 2 , Jalali M 1 , Miri R 3 , Amri A 1 , Shidfar SH 4

1 School of Health, Iran University of Medical Sciences, [email protected], IR Iran

2 School of Public Health, Tehran University of Medical Sciences, IR Iran

3 Shaheed Beheshti University of Medical Sciences

4 dMemorial Hospital, University of Massachusetts, USA

How to Cite: F S, A K, M J, R M, A A, et al. Effects of Purified Omega-3 Fatty Acids on Serum Lipoproteins and Malondialdehyde in Postmenopausal Fat Women Receiving Hormone Replacement Therapy, Int J Endocrinol Metab. Online ahead of Print ; 2(2):87-94.

ARTICLE INFORMATION

International Journal of Endocrinology and Metabolism: 2 (2); 87-94
Published Online: September 1, 2004
Article Type: Original Article
READ FULL TEXT

Abstract

Introduction: Regular intake of n-3 fatty acids of marine origin have desirable effects on serum lipoproteins and reduce coronary vascular disease (CVD). n-3 fatty acid supplementation decreased serum triglyceride concentrations in studies in which most of the subjects were male. The effects of n-3 fatty acids supplementation in fat women especially postmenopausal fat women have received little attention. The aim of this study was to determine whether purified n-3 fatty acids have desirable effects on serum lipoproteins, malondialdehyde (MDA) and lipoprotein risk factors for CVD in postmenopausal fat women receiving hormone replacement therapy (HRT).

Materials and Methods: In a double-blind, placebo-controlled trial of parallel design, 35 postmenopausal women receiving hormone replacement therapy were randomly allocated to receive 2 g purified n-3 fatty acids or placebo for 10 weeks. Serum lipoproteins and MDA were determined on days 0 and 70.

Results: Serum levels of triglycerides (TG) decreased significantly in the n-3 fatty acids group at the end of study compared to the initial values, and also compared to control group (26%, p< 0.003 and 29%, p< 0.01, respectively)_In the n-3 fatty acids group, serum levels of TG/HDL-C decreased significantly at the end of the study compared to initial values and, at the end of the study, compared to control group as well (23 %, P <0.05 and 28%, p< 0.05).

Conclusion: Supplementation with purified n-3 fatty acids can favorably influence selected CHD risk factors, particulary by achieving marked reduction in serum TG and TG/HDL-C levels in postmenopausal fat women receiving HRT.

Full Text

Full text is available in PDF

© 2004, International Journal of Endocrinology and Metabolism. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
COMMENTS

LEAVE A COMMENT HERE: