Acromegaly Associated with Leukemia: A Case Report

AUTHORS

MH Adib 1 , A Ebadi 2 , *

1 Department of Medical Oncology, Kashan University of Medical Sciences, I.R. Iran

2 Department of Endocrinology, Department of Endocrinology, Kashan University of Medical Sciences, [email protected], I.R. Iran

How to Cite: Adib M, Ebadi A. Acromegaly Associated with Leukemia: A Case Report, Int J Endocrinol Metab. Online ahead of Print ; 7(1):46-50.

ARTICLE INFORMATION

International Journal of Endocrinology and Metabolism: 7 (1); 46-50
Article Type: Case Report
Received: January 10, 2009
Accepted: February 19, 2009
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Abstract

Acromegaly is one of the most common clinical presentations of pituitary tu-mors. Some patients with this condi-tion may be affected by other benign or malignant neoplasms. There are a few reports of acromegaly in association with acute leukemias.
Case report: Reported here is a case of acromega-ly associated with Philadelphia positive acute lymphoblastic leukemial. The patient was a 61 year-old man, evaluated for complaints of bleed-ing from pilonidal cyst and weakness. He had typical acromegalic features. Laboratory tests showed he had pancytopernia and elevated IGF-1 levels. Imaging studies revealed he had a pitui-tary macroadenoma. The result of aspiration and biopsy of bone marrow and flowcytometric analysis confirmed the diagnosis of acute lym-phoblastic leukemia, Pre B cell type. Cytogenetic study of lymphoblasts revealed translocation of the 9 and 22 or Philadelphia chromosome.
Conclusion: It is suggested that the proliferative effect of growth hormone, as well as its anti-apoptotic activity related to IGF-1 may result in the increased incidence of neoplastic processes including acute leukemias in this group of pa-tients.

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