To compare the efficacy and safety of Diane 35 plus spironolactone and Diane 35 plus finasteride in the treatment of hirsutism and acne. Materials and Methods: A prospective randomized clinical trial was conducted on 120 Indian women with hirsutism. Group I patients were treated with Diane 35 plus spironolactone 100 mg daily and group II patients with Diane 35 plus finasteride 5 mg daily for 12 months. Hirsutism and acne score were graded every 3 months, for 18 months. The basal gonadotropins levels and androgens level were measured before the study. Statistical analysis was done by Student‘s t-test and repeated measure analysis followed by post hoc comparison. Results: Reduction in hirsutism and acne scores assessed every 3 months was significant (p<0.001) and similar between the two groups, indicating that if treatment was prolonged for over 12 months, reduction scores would have been better. A significant decrease in the hirsutism score of 55.3%±17.2 and 59.4%±17.5 was observed after 12 months in groups I and II respectively. Total reduction in hirsutism & acne scores of both groups was similar (P>0.05). Conclusion: Diane 35 plus spironolactone and Diane 35 plus finasteride are equally effective and safe in the treatment of hirsutism and acne. For better outcomes, it is recommended that the treatment period be over 12 months.

"/> To compare the efficacy and safety of Diane 35 plus spironolactone and Diane 35 plus finasteride in the treatment of hirsutism and acne. Materials and Methods: A prospective randomized clinical trial was conducted on 120 Indian women with hirsutism. Group I patients were treated with Diane 35 plus spironolactone 100 mg daily and group II patients with Diane 35 plus finasteride 5 mg daily for 12 months. Hirsutism and acne score were graded every 3 months, for 18 months. The basal gonadotropins levels and androgens level were measured before the study. Statistical analysis was done by Student‘s t-test and repeated measure analysis followed by post hoc comparison. Results: Reduction in hirsutism and acne scores assessed every 3 months was significant (p<0.001) and similar between the two groups, indicating that if treatment was prolonged for over 12 months, reduction scores would have been better. A significant decrease in the hirsutism score of 55.3%±17.2 and 59.4%±17.5 was observed after 12 months in groups I and II respectively. Total reduction in hirsutism & acne scores of both groups was similar (P>0.05). Conclusion: Diane 35 plus spironolactone and Diane 35 plus finasteride are equally effective and safe in the treatment of hirsutism and acne. For better outcomes, it is recommended that the treatment period be over 12 months.

"/>

A Comparative Study of Diane?35 plus Spironolactone and Diane ?35 Plus Finasteride in Cases of Hirsutism and Acne

AUTHORS

A Kriplani 1 , * , J Thulkar 2 , N Agrawal 2 , V Kulshrestha 2 , AC Ammini 2 , G Kumar 2

1 Department of Obstetrics and Gynecology, [email protected], India

2 Department of Obstetrics and Gynecology, India

How to Cite: Kriplani A, Thulkar J, Agrawal N, Kulshrestha V, Ammini A, et al. A Comparative Study of Diane?35 plus Spironolactone and Diane ?35 Plus Finasteride in Cases of Hirsutism and Acne, Int J Endocrinol Metab. Online ahead of Print ; 7(4):235-241.

ARTICLE INFORMATION

International Journal of Endocrinology and Metabolism: 7 (4); 235-241
Article Type: Original Article
Received: November 14, 2008
Accepted: November 7, 2009
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Abstract

To compare the efficacy and safety of Diane 35 plus spironolactone and Diane 35 plus finasteride in the treatment of hirsutism and acne. Materials and Methods: A prospective randomized clinical trial was conducted on 120 Indian women with hirsutism. Group I patients were treated with Diane 35 plus spironolactone 100 mg daily and group II patients with Diane 35 plus finasteride 5 mg daily for 12 months. Hirsutism and acne score were graded every 3 months, for 18 months. The basal gonadotropins levels and androgens level were measured before the study. Statistical analysis was done by Student‘s t-test and repeated measure analysis followed by post hoc comparison. Results: Reduction in hirsutism and acne scores assessed every 3 months was significant (p<0.001) and similar between the two groups, indicating that if treatment was prolonged for over 12 months, reduction scores would have been better. A significant decrease in the hirsutism score of 55.3%±17.2 and 59.4%±17.5 was observed after 12 months in groups I and II respectively. Total reduction in hirsutism & acne scores of both groups was similar (P>0.05). Conclusion: Diane 35 plus spironolactone and Diane 35 plus finasteride are equally effective and safe in the treatment of hirsutism and acne. For better outcomes, it is recommended that the treatment period be over 12 months.

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