Although the decline in sex steroid levels, particularly estradiol, may be largely responsible for age-related bone loss and osteoporotic fractures in older women, the insulin-like growth factor (IGF) system may also play a key role. This study aimed at evaluating the relation between the secretory status of growth hormones (GH), insulin-like growth factor I (IGF-I) and In-sulin-like growth factor binding protein 3 (IGFBP3) and bone mineral density (BMD) in postmenopausal women. Materials & Methods: In a descriptive cross-sectional study, 150 postmenopausal healthy women were selected from among 1328 patients, referred to Tabriz Sina Hospital for bone densi-tometry, and divided into three groups according to their bone mineral density (BMD) (normal, os-teopenic and osteoporotic). The GH response to provocation by clonidine was assessed in all pa-tients. Results: One hundred and fifty patients with a mean age of 65.6±6.6 years, were enrolled in this study. The impaired GH response to provocation by clonidine was significantly more common in the group with osteoporosis compared to their healthy and osteopenic counterparts (72% vs. 56% and 44%, respectively; p=0.018). Mean levels of serum IGF-I and IGFBP3 were not signifi-cantly different in healthy, osteopenic and os-teoporotic patients (55.4±20.7 μg/L, 57.5±21.7 μg/L, and 56.7±19.2 μg/L; p=0.880 and 2648.3±786.4 ng/ml, 2374.0±707.2 ng/ml, and 2613.5±1023.6 ng/ml; p=0.217, respectively). There was no strong cor-relation between the level of serum IGF-I or IGFBP3 and T-Score (r=-0.026, p=0.753 for IGF-1 and r=0.046, p=0.575 for IGFBP3). Conclusion: The results of this study showed that the defective release of GH is more prevalent in postmenopausal women suffering from osteoporosis; such a defect was not observed regarding serums of IGF1 and IGFBP3. Prescription of supplementary doses of synthetic GH might be beneficial in this population.

"/> Although the decline in sex steroid levels, particularly estradiol, may be largely responsible for age-related bone loss and osteoporotic fractures in older women, the insulin-like growth factor (IGF) system may also play a key role. This study aimed at evaluating the relation between the secretory status of growth hormones (GH), insulin-like growth factor I (IGF-I) and In-sulin-like growth factor binding protein 3 (IGFBP3) and bone mineral density (BMD) in postmenopausal women. Materials & Methods: In a descriptive cross-sectional study, 150 postmenopausal healthy women were selected from among 1328 patients, referred to Tabriz Sina Hospital for bone densi-tometry, and divided into three groups according to their bone mineral density (BMD) (normal, os-teopenic and osteoporotic). The GH response to provocation by clonidine was assessed in all pa-tients. Results: One hundred and fifty patients with a mean age of 65.6±6.6 years, were enrolled in this study. The impaired GH response to provocation by clonidine was significantly more common in the group with osteoporosis compared to their healthy and osteopenic counterparts (72% vs. 56% and 44%, respectively; p=0.018). Mean levels of serum IGF-I and IGFBP3 were not signifi-cantly different in healthy, osteopenic and os-teoporotic patients (55.4±20.7 μg/L, 57.5±21.7 μg/L, and 56.7±19.2 μg/L; p=0.880 and 2648.3±786.4 ng/ml, 2374.0±707.2 ng/ml, and 2613.5±1023.6 ng/ml; p=0.217, respectively). There was no strong cor-relation between the level of serum IGF-I or IGFBP3 and T-Score (r=-0.026, p=0.753 for IGF-1 and r=0.046, p=0.575 for IGFBP3). Conclusion: The results of this study showed that the defective release of GH is more prevalent in postmenopausal women suffering from osteoporosis; such a defect was not observed regarding serums of IGF1 and IGFBP3. Prescription of supplementary doses of synthetic GH might be beneficial in this population.

"/>

Relation Between Secretory Status of Growth Hormone, Serum Concentration of Insulin-like Growth Factor I, and Insulin-like Growth Factor Binding Protein 3 with Bone Mineral Density in Postmenopausal Women

AUTHORS

A Aliasgharzadeh 1 , * , A Bahrami 2 , F Najafipoor 2 , A Astanei 2 , M Niafar 2 , N Aghamohammadzadeh 2 , M Mobasseri 2

1 Endocrine and Metabolism Research Center, Emamreza Teaching Hospital Faculty of Medicine, Tabriz University of Medical Sciences, [email protected], IR.Iran

2 Endocrine and Metabolism Research Center, Emamreza Teaching Hospital Faculty of Medicine, Tabriz University of Medical Sciences, IR.Iran

How to Cite: Aliasgharzadeh A, Bahrami A, Najafipoor F, Astanei A, Niafar M, et al. Relation Between Secretory Status of Growth Hormone, Serum Concentration of Insulin-like Growth Factor I, and Insulin-like Growth Factor Binding Protein 3 with Bone Mineral Density in Postmenopausal Women, Int J Endocrinol Metab. Online ahead of Print ; 6(2):78-88.

ARTICLE INFORMATION

International Journal of Endocrinology and Metabolism: 6 (2); 78-88
Article Type: Original Article
Received: February 13, 2007
Accepted: February 1, 2008
READ FULL TEXT

Abstract

Although the decline in sex steroid levels, particularly estradiol, may be largely responsible for age-related bone loss and osteoporotic fractures in older women, the insulin-like growth factor (IGF) system may also play a key role. This study aimed at evaluating the relation between the secretory status of growth hormones (GH), insulin-like growth factor I (IGF-I) and In-sulin-like growth factor binding protein 3 (IGFBP3) and bone mineral density (BMD) in postmenopausal women. Materials & Methods: In a descriptive cross-sectional study, 150 postmenopausal healthy women were selected from among 1328 patients, referred to Tabriz Sina Hospital for bone densi-tometry, and divided into three groups according to their bone mineral density (BMD) (normal, os-teopenic and osteoporotic). The GH response to provocation by clonidine was assessed in all pa-tients. Results: One hundred and fifty patients with a mean age of 65.6±6.6 years, were enrolled in this study. The impaired GH response to provocation by clonidine was significantly more common in the group with osteoporosis compared to their healthy and osteopenic counterparts (72% vs. 56% and 44%, respectively; p=0.018). Mean levels of serum IGF-I and IGFBP3 were not signifi-cantly different in healthy, osteopenic and os-teoporotic patients (55.4±20.7 μg/L, 57.5±21.7 μg/L, and 56.7±19.2 μg/L; p=0.880 and 2648.3±786.4 ng/ml, 2374.0±707.2 ng/ml, and 2613.5±1023.6 ng/ml; p=0.217, respectively). There was no strong cor-relation between the level of serum IGF-I or IGFBP3 and T-Score (r=-0.026, p=0.753 for IGF-1 and r=0.046, p=0.575 for IGFBP3). Conclusion: The results of this study showed that the defective release of GH is more prevalent in postmenopausal women suffering from osteoporosis; such a defect was not observed regarding serums of IGF1 and IGFBP3. Prescription of supplementary doses of synthetic GH might be beneficial in this population.

Full Text

Full text is available in PDF

© 0, International Journal of Endocrinology and Metabolism. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
COMMENTS

LEAVE A COMMENT HERE: