This review examines the role of the basal insu-lin analogue, insulin glargine in the treatment of type 2 diabetes, focusing on how research evi-dence can inform its use in clinical practice. The importance of achieving optimal glycaemic con-trol has been emphasised by bodies such as the IDF who have set strict targets for HbA1c levels. We know that FPG plays an important role in helping to achieve optimal glycaemic control and basal insulin therapy can play a role in this area. Insulin glargine is a once-daily, peakless basal insulin which has been shown to achieve the same degree of glycaemic control as NPH insulin but with significantly reduced rates of hypogly-caemia. This allows patients to improve self management of their diabetes by optimising treatment without the risk of hypoglycaemia. Research has shown that patients can safely op-timise therapy with a patient-led titration algo-rithm based on an insulin dose adjustment of 2 units every 3 days. Initiation of insulin glargine has been shown to be effective within a group as well as individually, allowing health care pro-fessionals to manage their time more effectively between the growing numbers of people requir-ing insulin therapy. Conclusions: This basal insulin analogue is a welcome addition to the plethora of treatments available to treat type 2 diabetes and efficacy data can now be converted into practical meth-ods of optimising insulin therapy for the type of patients healthcare professionals routinely en-counter in their practice.

"/> This review examines the role of the basal insu-lin analogue, insulin glargine in the treatment of type 2 diabetes, focusing on how research evi-dence can inform its use in clinical practice. The importance of achieving optimal glycaemic con-trol has been emphasised by bodies such as the IDF who have set strict targets for HbA1c levels. We know that FPG plays an important role in helping to achieve optimal glycaemic control and basal insulin therapy can play a role in this area. Insulin glargine is a once-daily, peakless basal insulin which has been shown to achieve the same degree of glycaemic control as NPH insulin but with significantly reduced rates of hypogly-caemia. This allows patients to improve self management of their diabetes by optimising treatment without the risk of hypoglycaemia. Research has shown that patients can safely op-timise therapy with a patient-led titration algo-rithm based on an insulin dose adjustment of 2 units every 3 days. Initiation of insulin glargine has been shown to be effective within a group as well as individually, allowing health care pro-fessionals to manage their time more effectively between the growing numbers of people requir-ing insulin therapy. Conclusions: This basal insulin analogue is a welcome addition to the plethora of treatments available to treat type 2 diabetes and efficacy data can now be converted into practical meth-ods of optimising insulin therapy for the type of patients healthcare professionals routinely en-counter in their practice.

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Achieving Glycaemic Targets in Type 2 Diabetes: the Role of the Basal Insulin Analogue Insulin Glargine and How to Use it in Clinical Practice: Moving from Evidence to Practice

AUTHORS

MJ Davies 1 , J Jarvis 2 , * , K Khunti 1

1 Department of Cardiovascular Sciences, University of Leicester, UK

2 Diabetes Research,University Hospital of Leicester, [email protected]a, UK

How to Cite: Davies M, Jarvis J, Khunti K. Achieving Glycaemic Targets in Type 2 Diabetes: the Role of the Basal Insulin Analogue Insulin Glargine and How to Use it in Clinical Practice: Moving from Evidence to Practice, Int J Endocrinol Metab. Online ahead of Print ; 6(1):38-49.

ARTICLE INFORMATION

International Journal of Endocrinology and Metabolism: 6 (1); 38-49
Article Type: Review Article
Received: January 31, 2007
Accepted: November 20, 2007
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Abstract

This review examines the role of the basal insu-lin analogue, insulin glargine in the treatment of type 2 diabetes, focusing on how research evi-dence can inform its use in clinical practice. The importance of achieving optimal glycaemic con-trol has been emphasised by bodies such as the IDF who have set strict targets for HbA1c levels. We know that FPG plays an important role in helping to achieve optimal glycaemic control and basal insulin therapy can play a role in this area. Insulin glargine is a once-daily, peakless basal insulin which has been shown to achieve the same degree of glycaemic control as NPH insulin but with significantly reduced rates of hypogly-caemia. This allows patients to improve self management of their diabetes by optimising treatment without the risk of hypoglycaemia. Research has shown that patients can safely op-timise therapy with a patient-led titration algo-rithm based on an insulin dose adjustment of 2 units every 3 days. Initiation of insulin glargine has been shown to be effective within a group as well as individually, allowing health care pro-fessionals to manage their time more effectively between the growing numbers of people requir-ing insulin therapy. Conclusions: This basal insulin analogue is a welcome addition to the plethora of treatments available to treat type 2 diabetes and efficacy data can now be converted into practical meth-ods of optimising insulin therapy for the type of patients healthcare professionals routinely en-counter in their practice.

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