Anti-thyroid drugs, methimazole, carbimazole and propylthiouracil are commonly prescribed for the treatment of hyperthyroidism due to Graves' disease_ We present here the report of a Caucasian patient with Graves' disease who developed ANCA positive propylthiouracil induced vasculitis_ The episode was characterised by a vasculitic skin rash associated with polyarthralgia but no renal involvement_ While carbimazole/ methimazole has a lower incidence of reported ANCA positive side effects than PTU, the use of the latter in pregnancy may still be considered as reasonable because the immunosuppression of pregnancy may prevent the appearance of immune problems.

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ARTICLE AUTHORS
ARTICLE INFO

Propylthiouracil Induced ANCA Positive Vasculitis: a Case Report

AUTHORS

Khanolkar MP 1 , Owen PJD 1 , Lazarus JH 2 , *

1 Department of Medicine, University of Wales College of Medicine, UK

2 Department of Medicine, University of Wales College of Medicine, [email protected], UK

How to Cite: MP K, PJD O, JH L. Propylthiouracil Induced ANCA Positive Vasculitis: a Case Report, Int J Endocrinol Metab. Online ahead of Print ; 2(1):47-50.

ARTICLE INFORMATION

International Journal of Endocrinology and Metabolism: 2 (1); 47-50
Article Type: Case Report
Received: January 1, 2003
Accepted: January 25, 2004
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Abstract

Anti-thyroid drugs, methimazole, carbimazole and propylthiouracil are commonly prescribed for the treatment of hyperthyroidism due to Graves' disease_ We present here the report of a Caucasian patient with Graves' disease who developed ANCA positive propylthiouracil induced vasculitis_ The episode was characterised by a vasculitic skin rash associated with polyarthralgia but no renal involvement_ While carbimazole/ methimazole has a lower incidence of reported ANCA positive side effects than PTU, the use of the latter in pregnancy may still be considered as reasonable because the immunosuppression of pregnancy may prevent the appearance of immune problems.

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