Mycoplasma pneumoniae and Recurrent Respiratory Tract Infection within One Year After Treatment in Infants, Risk Factors and prevalence

AUTHORS

Cheng-Yi Wang ORCID 1 , 2 , Chao-Min Song 3 , * , Guang-Hua Liu ORCID 1

1 Department of Pediatrics, Fujian Maternity and Children Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou, China

2 Engineering Research Center for Medical Data Mining and Application of Fujian Province, Fuzhou, China

3 Department of Neonatology, Fujian Maternity and Children Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou, China

How to Cite: Wang C, Song C, Liu G. Mycoplasma pneumoniae and Recurrent Respiratory Tract Infection within One Year After Treatment in Infants, Risk Factors and prevalence, Iran J Pediatr.2021 31(3): e112283. doi: 10.5812/ijp.112283.

ARTICLE INFORMATION

Iranian Journal of Pediatrics: 31 (3); e112283
Published Online: June 05, 2021
Article Type: Research Article
Received: December 29, 2020
Revised: April 05, 2021
Accepted: April 20, 2021
Primary Published scheduled for 31 (4)
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Abstract

Background: Mycoplasma pneumoniae pneumonia (MPP) is common in pediatric patients. Many study showed that recurrent respiratory tract infections (RRTIs) are common in the year following treatment of MPP in infants, but the factors associated with the occurrence of RRTIs are rarely reported. Therefore, the aim of the present study was to identify these factors.

Methods: This retrospective observational study included infants (<1years) who were clinically treated for MPP from January 2015 to December 2018. Clinical featuresand relevant data on admission were collected. The cases for the occurrence of RRTIs and the presence of related factors after 1 year of follow-up by questionnaires were investigated. The questionnaires contained number of upper respiratory infections , tracheobronchitis, pneumonia; the titers and course of MP-IgG and positive IgM antibody; eczema; pet ownership; interior decoration; inhaled or ingested allergens; exposure to environmental tobacco smoke, and gastrointestinal function. Independent significant risk factors for RRTIs were identified using binary logistic regression.

Results: A total of 300 MPP cases were included, out of which RRTIs occurred in 134 cases (44.7%) in the year following MPP treatment. Binary logistic regression analysis showed that a history of prematurity (OR= 6.336, 95% CI: 2.337–17.116, P ≤0.001), a history of exposure to inhaled or ingested allergens (OR =2.527, 95% CI: 1.289–4.956, P = 0.007), and co-infection involving Chlamydia pneumoniae (OR = 2.787, 95% CI: 1.145–6.784, P = 0.024) were significantly and positively associated with RRTIs after MPP, while age (OR = 0.894, 95% CI: 0.825–0.970, P = 0.007) showed a negative correlation with RRTIs.

Conclusions: RRTIs in the year following clinical treatment of MPP in infants is relatively common and is significantly associated with the patient’s age,history of prematurity,history of exposure to in haledor ingested allergens,and C.pneumoniae co-infection.Thus,these factors should becarefully assessed in pediatric MPP cases in order to predict the risk of RRTIs and appropriately manage the patient.

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© 2021, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
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