Platelets in Pulmonary Hypertension: a Causative Role or a Simple Association?

AUTHORS

Keyhan Sayadpour Zanjani 1 , *

1 Pediatric Center of Excellence, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran

How to Cite: Sayadpour Zanjani K . Platelets in Pulmonary Hypertension: a Causative Role or a Simple Association?, Iran J Pediatr. 2015 ; 22(2):145-157.

ARTICLE INFORMATION

Iranian Journal of Pediatrics: 22 (2); 145-157
Published Online: June 30, 2012
Article Type: Review Article
Received: September 05, 2011
Accepted: February 11, 2012
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Abstract

Pathophysiology of pulmonary arterial hypertension is based on three basic mechanisms: thrombotic pulmonary vascular lesions, vasoconstriction and vascular remodeling. Platelets are related to all of these mechanisms by their aggregation, production, storage and release of several mediators. The role of platelets is more prominent in some types of pulmonary arterial hypertension, including those which are secondary to inflammatory and infectious diseases, hemoglobinopathies, essential thrombocythemia, drugs, thrombo-embolism, and cardiac surgery. Most pulmonary antihypertensive drugs have a negative effect on platelets. In this review, the mechanisms of platelets association with pulmonary arterial hypertension, those types of pulmonary arterial hypertension with greatest platelet contribution to their pathophysiology, and the effects of pulmonary antihypertensive drugs on platelets are summarized.

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  • © 2015, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
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