Hepatic Involvement in Dengue Fever in Children


Lingappa Umesh 1 , Vaddambal G. Manjunath 1 , K JAGADISHKUMAR 1 , *

1 Department of Pediatrics, JSS Medical College, JSS University, Mysore, India

How to Cite: Umesh L, G. Manjunath V, JAGADISHKUMAR K . Hepatic Involvement in Dengue Fever in Children, Iran J Pediatr. 2015 ; 22(2):231-236.


Iranian Journal of Pediatrics: 22 (2); 231-236
Published Online: June 30, 2012
Article Type: Research Article
Received: May 15, 2011
Accepted: January 04, 2012


Objective: Hepatic dysfunction is common in dengue infection and the degree of liver dysfunction in children varies from mild injury with elevation of transaminases to severe injury with jaundice. This study was undertaken to assess the spectrum of hepatic involvement in dengue infection.
Methods: 110 children with serologically positive dengue fever aged between 2 months - 14 years were studied for their hepatic functions both clinically and biochemically after excluding malaria, enteric fever, Hepatitis A and Hepatitis B with relevant investigations.
Findings: All cases were grouped into DF (Dengue fever), DHF (Dengue hemorrhagic fever) and DSS (Dengue shock syndrome) according to WHO criteria. The spectrum of hepatic manifestations included hepatomegaly (79%), hepatic tenderness (56%), jaundice (4.5%), raised levels of aspartate transaminase (AST)(93 %), alanine transaminase (ALT)(78%), alkaline phosphatase (AP) (57%), prolonged prothrombin time (PT) (20%), reduced levels of serum albumin (66%) and abnormal abdomen ultrasound (65%).
Conclusion: Hepatic dysfunction was observed more in DHF and DSS group compared to DF group. About 17.27% of children had >10 fold increase in the liver enzymes. There was no correlation between the degree of hepatic enlargement or hepatic tenderness with the abnormalities of liver functions. Any child with fever, jaundice and tender hepatomegaly in geographical areas where dengue is endemic, the diagnosis of dengue infection should be strongly considered.




  • 1.

    References are available in PDF.

  • © 2015, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.