Interstitial Lung Disease in a Patient with Chronic Granulomatous Disease

AUTHORS

Nima Rezaei 1 , Sara Kashef 2 , Mozhgan Moghtaderi 2 , *

1 Research Group for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran & Molecular Immunology Research Center; and Department of Immunology, Tehran University of Medical Sciences, Tehran, Iran

2 Allergy Research Center, Shiraz University of Medical Sciences, Shiraz & Department of Pediatrics, Division of Immunology and Allergy, Shiraz University of Medical Sciences, Shiraz, Iran

How to Cite: Rezaei N, Kashef S, Moghtaderi M. Interstitial Lung Disease in a Patient with Chronic Granulomatous Disease, Iran J Pediatr. 2016 ; 22(1):129-132.

ARTICLE INFORMATION

Iranian Journal of Pediatrics: 22 (1); 129-132
Published Online: March 31, 2012
Article Type: Case Report
Received: October 27, 2010
Accepted: March 03, 2011
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Abstract

Background: Chronic granulomatous disease (CGD) is an inherited phagocytes defect, characterized by defects of NADPH-oxidase and inability of bacterial killing, which leads to recurrent life-threatening infections. Respiratory problems, which are the major cause of morbidity in CGD, usually result from recurrent severe infections; however, vigorous inflammatory response could also cause respiratory diseases.
Case Presentation: Herein, an 11 year-old patient with CGD is presented who suffered from chronic cough and dyspnea for 7 years. Considering the results of chest X-ray, high-resolution computed tomography, and pulmonary function test, the diagnosis of interstitial lung disease was made.
Conclusion: Early recognition of manifestations associated with CGD and appropriate treatment could prevent further complications and reduce morbidity and mortality in this group of patients.

 

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