Does Cigarette Smoking Have a Protective Effect Against Parkinson's Disease?


Seyed Ali Masoud 1 , *

1 Associate professor of Neurology, Kashan University of Medical Sciences, Kashan, Iran

How to Cite: Masoud S A. Does Cigarette Smoking Have a Protective Effect Against Parkinson's Disease?, Iran J Psychiatry Behav Sci. 2008 ; 2(2):46-9.


Iranian Journal of Psychiatry and Behavioral Sciences: 2 (2); 46-9
Published Online: July 31, 2008
Article Type: Original Article
Received: June 09, 2008
Accepted: July 09, 2008


Objective: Previous studies reported that individuals with Parkinson’s disease are less likely to have smoking history and it seems that nicotine has a neuroprotective effect. The authors have conducted a casecontrol retrospective study to determine if there is an association between cigarette smoking and Parkinson’s disease.

Methods: In a matched case-control study, 92 individuals with Parkinson’s disease (71 men, 21 women; mean age: 67.3±11 year) were compared to 184 people without such a diagnosis. (144 men, 40 women; mean age: 65.7±12.3 year).

Results: Nineteen patients in the group with a diagnosis of Parkinson’s disease (20.6%) were smoker. In the control group, however, there were 103 smokers. Also, we found a dose-response correlation between amount of smoking and higher risk of having Parkinson’s diseas.

Conclusion: Consistent with the results of previous studies, we found that individuals with Parkinson’s disease are significantly less likely to have smoked regularly than those without Parkinson’s disease.


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  • © 2008, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.