The Pattern of Adherence in Patients with Bipolar I Disorder; an Eight Weeks Study


Ali Sharifi 1 , Amir Shabani 1 , Masoud Ahmadzad-Asl 2 , *

1 Tehran Psychiatric Institute, Mental Health Research Centre, Iran University of Medical Sciences and Health Services, Tehran, Iran

2 Tehran Psychiatric Institute, Mansouri St, Niyayesh St, Sattarkhan Ave, Tehran, Iran

How to Cite: Sharifi A, Shabani A, Ahmadzad-Asl M. The Pattern of Adherence in Patients with Bipolar I Disorder; an Eight Weeks Study, Iran J Psychiatry Behav Sci. 2009 ; 3(2):39-43.


Iranian Journal of Psychiatry and Behavioral Sciences: 3 (2); 39-43
Published Online: December 31, 2009
Article Type: Original Article
Received: July 05, 2009
Accepted: September 29, 2009


Objectives: Non-adherence limits the effectiveness of medications among patients with bipolar disorder. Many studies have investigated the predicting factors of non-adherence. This paper aims to present the pattern of adherence in patients with bipolar I disorder (BID).

Methods: Seventy six patients with BID enrolled in a prospective study. The Medication Possession Ratio (MPR) was used to evaluate patients' adherence to medications, and repeated measure analysis was performed to reveal the pattern of variations. A Persian translation of Drug Attitude Inventory (DAI-10) (shortened version) was used to assess the attitude of patients toward medications.

Results: the repeated measure analysis revealed that the adherence to medications successively decreased (p<0.001). Age, gender, marital status, educational level, comorbid substance abuse did not alter the pattern.

Conclusion: There is a decreasing pattern in the adherence to medications among BID patients, regardless of known predicting factors of non-adherence. It means even fully adherent patients could potentially become non-adherents during the course of maintenance treatment.


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