Fragile X Mental Retardation Protein is Reduced in Cerebella of Subjects with Autism

AUTHORS

Seyyed Hossein Fatemi 1 , * , Timothy D Folsom 2

1 Department of Psychiatry, Division of Neuroscience Research, University of Minnesota Medical School, 420 Delaware St SE, MMC 392, MN 55455 USA, Minneapolis, United States

2 Departments of Pharmacology and Neuroscience, University of Minnesota Medical School, Minnesota, United States

How to Cite: Fatemi S H, D Folsom T. Fragile X Mental Retardation Protein is Reduced in Cerebella of Subjects with Autism, Iran J Psychiatry Behav Sci. 2010 ; 4(2):56-7.

ARTICLE INFORMATION

Iranian Journal of Psychiatry and Behavioral Sciences: 4 (2); 56-7
Published Online: December 31, 2010
Article Type: Brief Report
Received: August 13, 2010
Accepted: August 24, 2010
READ FULL TEXT

Abstract

Autism and fragile X syndrome have multiple behavioral phenotypes in common, however there has been little research into the potential role of fragile X mental retardation protein (FMRP) in autism. We sought to measure protein levels of FMRP in the lateral cerebella of subjects with autism and matched controls. We found significantly reduced levels of FMRP (p<0.0063) in subjects with autism. The loss of FMRP expression in subjects with autism may help explain behavioral deficits, presence of seizure, and reduction in GABA receptors in subjects with autism.

Declaration of interest: None

Fulltext

Full text is available in the PDF.

References

  • 1.

    References are available in the PDF.

  • © 2010, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
    COMMENTS

    LEAVE A COMMENT HERE: