Differentiation of Fanconi and Aplastic Anemia Using Chromosomal Breakage Test in Southern Iran

AUTHORS

Sh Farjadian 1 , F Azad 1 , MR Bordbar 1 , M Karimi 2 , *

1 Department of Immunology, Shiraz University of Medical Sciences, Fars, Iran

2 Professor of Pediatric Hematology-Oncology, Hematology Research Center, Nemazee Hospital, Department of Pediatrics, Shiraz University of Medical Sciences, [email protected], Fars, Iran

How to Cite: Farjadian S, Azad F, Bordbar M, Karimi M. Differentiation of Fanconi and Aplastic Anemia Using Chromosomal Breakage Test in Southern Iran, Iran Red Crescent Med J. Online ahead of Print ; 10(4):323-325.

ARTICLE INFORMATION

Iranian Red Crescent Medical Journal: 10 (4); 323-325
Article Type: Brief Report
Received: April 2, 2008
Accepted: July 15, 2008
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Abstract

Background: Fanconi anemia (FA) is a chromosomal breakage disorder characterized by familial aplastic anemia (AA), various congenital anomalies, and a characteristic chromosomal response to clastogenic stress.

 

Methods: In this study, chromosome breakage test was performed for 38 patients suspected of having FA and age-matched controls.

 

Results: According to the results, ten patients were considered as FA cases and 15 patients with no chromosomal breaks were considered as AA.

 

Conclusion: Differentiation of FA from AA is very important because the primary treatment is different. This test should be done in every primary presentation of AA.

 

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