The Comparative Effects of Atorvastatin and Quince Leaf Extract on Atherosclerosis


Farzaneh Khademi 1 , * , Behnam Danesh 1 , Daruosh Mohammad Nejad 2

1 Department of Tissue Engineering and Cell Therapy, Faculty of Advanced Medical Technologies, Tehran University of Medical Sciences, Tehran, IR Iran

2 Department of Anatomical Sciences, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, IR Iran

How to Cite: Khademi F, Danesh B, Mohammad Nejad D. The Comparative Effects of Atorvastatin and Quince Leaf Extract on Atherosclerosis, Iran Red Crescent Med J. Online ahead of Print ; 15(8):639-643. doi: 10.5812/ircmj.4030.


Iranian Red Crescent Medical Journal: 15 (8); 639-643
Published Online: August 4, 2013
Article Type: Research Article
Received: December 31, 2011
Accepted: June 30, 2013


Background: This study investigates the ability of quince leaf extract to prevent progression of atherosclerosis and to determine the lipid-lowering effect of it.

Objectives: This study suggested that quince leaf effects on progression of atherosclerosis, and comparison with atorvastatin as a standard medication.

Materials and Methods: The effect of 50mg/kg of the quince leaf extract on lipid profiles was assessed by measuring the levels of totalcholesterol, triglyceride, LDL, HDL, and liver enzymes (AST, ALT, and AP) in plasma and were evaluated the thickness of aortic plaques in the hypercholesterolemic rabbits after stopping. These assessments were performed using 0.5 mg/kg of atorvastatin.

Results: Oral administration of cholesterol for 8 weeks resulted in a significant increase (P < 0.05) in plasma markers. Treatment with the extract at dose of 50 mg/kg and 0.5 mg/kg of atorvastatin not only were reduced lipid profile in plasma (P < 0.05) but also were increased HDL-cholesterol levels. There were decrease (P = 0.04) in the liver enzymes in extract treated rabbits. However, plaque thickness had no significant difference in the aorta of treated rabbits compared with studied control.

Conclusions: These results indicate the lipid-lowering effects of quince leaf similar to atorvastatin and it can probably serve as a new potential natural product for atherosclerosis treatment.

© 2013, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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