Cytomegalovirus Infection and Coronary Artery Disease: A Single- Center Serological Study in Northwestern Iran


Zakieh Rostamzadeh Khameneh 1 , Alireza Rostamzadeh 2 , Mohaddeseh Nemati 3 , Paul M. Brown 4 , Nariman Sepehrvand 5 , *

1 Department of Microbiology and Immunology, Urmia University of Medical Sciences, Urmia, Iran

2 Department of Cardiology, Urmia University of Medical Sciences, Urmia, Iran

3 Department of Biochemistry, Urmia University of Medical Sciences, Urmia, Iran

4 Department of Medicine, University of Alberta, Edmonton, Alberta, Canada

5 Students’ Research Committee, Urmia University of Medical Sciences, Urmia, IR Iran, Iran

How to Cite: Rostamzadeh Khameneh Z , Rostamzadeh A , Nemati M , Brown P M, Sepehrvand N . Cytomegalovirus Infection and Coronary Artery Disease: A Single- Center Serological Study in Northwestern Iran, Int Cardio Res J. 2016 ; 10(3):e10167.


International Cardiovascular Research Journal: 10 (3); e10167
Published Online: September 15, 2016
Article Type: Research Article
Received: August 07, 2015
Revised: January 09, 2016
Accepted: February 29, 2016


The role of chronic Cytomegalovirus (CMV) infection and inflammation in the pathogenesis of atherosclerosis and Coronary Artery Disease (CAD) is still not clear.
This study aimed to explore the seroprevalence of anti-CMV antibodies and inflammatory markers in patients with stable angina who had undergone diagnostic coronary angiography for clinical suspicion of CAD.
Patients and Methods:
This cross-sectional, descriptive study was conducted on 181 patients with stable angina selected randomly among the patients referred to Seyyedoshohada Heart Hospital of Urmia, Iran for diagnostic coronary angiography between August 2012 and December 2013. The patients were categorized into CAD and non-CAD groups based on their angiographic findings. Then, anti-CMV IgG and IgM antibodies were tested using the Enzyme-Linked Immunosorbent Assay (ELISA) method (Diapron, Rome, Italy). Serum C-Reactive Protein (CRP) was also measured by a qualitative method (Aniston Kit).
Based on angiographic findings, 141 patients (77.9%) had atheromatous plaques in their coronary arteries, while coronary arteries were free of any plaques in 40 cases (22.1%). Besides, 99.3% of the patients in the CAD group and all the patients in the non-CAD group were anti-CMV IgG positive. The rate of anti-CMV IgM seropositivity was 11.7% in the CAD group and 13.2% in the non-CAD group (P = 0.78). However, no significant difference was observed between the groups with and without angiographically-documented CAD in terms of CRP seropositivity (64.7% vs. 56.4%, P = 0.34).
Regardless of having angiographically-proven CAD, almost all the cases referred for coronary angiography in our study had a previous exposure to CMV infection as determined by the presence of anti-CMV IgG antibodies in their sera. In fact, the results indicated no significant associations between CMV infection and the presence of CAD.



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